2538 results
The goal of the project is to validate the developed standardized atrophy measurement method at VU University Medical Centre in patients with MS. This is done by testing how well the measurements of atrophy agree between different scanners and…
The main objective of this study is to evaluate the differences in [18F]FEOBV binding between PD patients and healthy control subjects, in order to evaluate the clinical feasibility of [18F]FEOBV as a cholinergic imaging ligand in PD. Secondary…
The primary objective is to assess neuropsychological function in X-ALD patients without active cerebral demyelinating disease. Data of minors will be compared to matched healthy controls. Data of adults will be compared to reference values. The…
DEfective HUman SAlivary gland stem cells: the cause of Primary Sjögren*s syndrome?
-DEHUSAPS study-
To assess whether salivary gland stem cell (SGCS) defects are key to salivary gland pathogenesis in pSS.
Investigating and comparing two disorders (i.e., OCD and GD) with phenomenological different types of compulsive behaviors central to their pathology can elucidate common mechanisms of compulsivity in psychiatry - core features- as well as specific…
The main purpose of this study is to determine the side effects of trastuzumab when it is given by each of these subcutaneous injection methods. The study will also gather information about whether and when the cancer comes back after taking…
The primary objective is to assess the 18-month incidence of inappropriate shocks in subjects implanted with the EMBLEM Subcutaneous Implantable Defibrillator (S-ICD) programmed with zone cutoffs at 200 bpm and 250 bpm and:- an indication for…
Main study:We want to assess whether bleeding risk in women with uterine leiomyomas is associated with CK activity and attenuated platelet aggregation.Objective of pilot study:Firstly, to perform a feasibility pilot of CK/AK measurement in menstrual…
The primary objective is to measure the longitudinal changes of PDE10A enzyme availability in the caudate, putamen, and globus pallidus of Huntington*s Disease Gene Expansion Carrier (HDGECs) by comparison of the follow-up and initial Positron…
Primary objectives:- To investigate possible differences in driving performances between premanifest gene carriers, manifest HD, and control subjects.- To explore if different aspects of cognitive functioning might be a predictor of fitness to drive…
The primary objective of the study is to assess the safety and tolerability of long-term open-label CP-690,550 therapy in subjects with CD.Secondary objectives are to evaluate the effect of CP-690,550 maintenance therapy on clinical remission and on…
This study aims at, first, assessing the most relevant exposure aspects of night-shift work and, second, identifying biomarkers for both acute and chronic circadian disruption associated to these specific nightshift work aspects. By applying…
The primary objective of this study is to assess whether the efficacy of ocrelizumab given as two dose regimens of 600 mg (given as 300 mg infusions on days 1 and 15 and 600 mg infusion in the following cycles) or 400 mg (given as 200 mg infusions…
Primary Objective:Pilot study: Selection of the titanium derivatives which are capable of penetrating the skin, and thus can be used in the full study as patch test materials.Full study: To compare the results of three different diagnostic tests…
The aim of this study is to explore the added value of the indol profile in comparison to serotonin in platelets and 5-HIAA in urine for diagnosis and potentially management of neuroendocrine tumors including gastrinomas, pNETs and brochopulmonary…
Hypothesis: gaseous signaling molecules influence placental vasomotor activity to compensate for hypoxemia. Metabolites of these vasoactive molecules can be found in the blood and urine and can indicate whether this (compensatory) mechanism is used…
The aim of this study is to determine whether male microchimerism is present in patients with MRKH syndrome. This would be a sign of intrauterine cell trafficking - and possible AMH transfer- from male to female co-twin. This placental blood…
The primary objective of the study is to determine whether patients with PA have a higher level of arterial wall inflammation than patients with essential hypertension. Secondary Objectives: To determine whether circulating monocytes of patients…
The main objective is to investigate the preparatory process in left primary motor cortex in relation to hand choice during whole-body motion.
The main goal of the study is to evaluate the feasibility of using 1) passive treadmill belt speed perturbations to measure spinal reflex activity in the calf muscles; and 2) active real-time visual feedback on dedicated gait parameters to highlight…