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DCE MRI in the follow-up of prostate cancer patients after radiotherapy; a matched case control stuy (Pilot)

To measure the differences of DCE MR images between patients with and without local recurrent prostate cancer in the follow up after primary treatment.

Open-label, non-randomized, positron emission tomography (PET) imaging study to evaluate a single dose of 250 MBq (6.75 mCi) ZK 6032924 (18F-FEDAA1106) for its diagnostic potential in discriminating patients with probable Alzheimerâ¤*s disease from healthy volunteers and to evaluate the radiation dosimetry of a single dose of 185 MBq (5 mCi) ZK 6032924 in healthy volunteers.

Discrimination of probable AD patients from healthy volunteers by ZK 6032924 PET imaging as evaluated by visual analysis of the brain distribution patterns and by SUV values in probable AD patients as compared to healthy volunteers for brain imaging…

Normal values for ventricle volumes and cerebrospinal fluid (CSF) circulation

Obtain normal values of ventricle volumes and CSF circulation in healthy volunteers with MRI scanning.

[123I] iodobenzamide single photon emission computer tomography of D2 receptors in obsessive-compulsive spectrum disorders

The primary goal of the proposed study is to investigate the dopamine D2 receptor binding potential in patients with body dysmorphic disorder (BDD) and patients with trichotillomania (TTM) in comparison to healthy subjects. As BDD and TTM are OC…

Emotion-Cognition Interaction in Psychotic Disorders

The main goal of our proposal is to study the interaction between cognitive and emotional capacities in schizophrenia. In numerous studies patients with schizophrenia show impairments in all major cognitive domains (6) as well as impairments in the…

Metabolic network activity and atrophy patterns in patients with parkinsonian disorders

Databases with multimodal brain imaging data (FDG-PET, VBM, DTI) will be created. From these data image features and network patterns will be extracted, to be used to create a supervised classification method for associating brain patterns to…

The effect of N-acetylcysteine and ascorbic acid on pulmonary arterial pressure and ventilation during normoxia, hypoxia and hyperoxia and total oxidant capacity.

In this study we will therefore investigate the influence of hypoxia and anti oxidants on HVR and HPV.

Validation of circulating tumor cells (CTC) detection techniques in patients with advanced solid tumors

In our opinion, CTCs could serve as a pharmacodynamic marker to monitor anti-cancer therapy in clinical trials. Encouraging results, that show that CTCs have pharmacodynamic properties, were recently found in a prospective trial in which CTC number…

Smellprints in lung Cancer; the role of ENose in diagnosis and Treatment (SCENT)
part 5: Diagnostic value of the eNose in Colorectal Cancer

The primary objective of this study is to examine the difference in VOC pattern of exhaled air (breathprint) between patients with histology-confirmed diagnosis of colorectal cancer and healthy controls. The secondary objectives are to investigate:…

Spatiotemporal properties of the flexion/extension movements of the cervical spine in patients with a chronic whiplash associated disorder and healthy controls

This study aims to investigate differences in spatiotemporal properties of the active movements in of the cervical spine in the sagittal plane in chronic WAD patients and healthy controls.

Towards prediction of speech recognition in cochlear implant users

The primary objective is to investigate the influence of auditory and non-auditory factors on speech recognition abilities in quiet and in noise in CI users. For this reason we will study the effects of linguistic skills and working memory capacity…

The microcirculation in children treated with extracorporeal membrane oxygenation;
an observational longitudinal study

To study whether microcirculatory perfusion is improved by ECMO. Perfusion will be studied before & after ECMO start, during ECMO weaning and before & after ECMO stop. To study the precictive value of perfusion and its correlation…

Case-control study: prevalence of cardiovascular riskfactors in formerly preeclamptic women and women with uncomplicated obstetric history.

Main objective:Have formerly preeclamptic women, 5 to 10 years post-partum, a higher prevalence of a cardiovascular riskprofile compared to women with uncomplicated pregancies in history.

Objective physical arm activity assessment

Primary objective:Study A: Development, validation and reproducibility of a method to assess arm activity.Study B: Investigate the association between muscle effort and arm use during a series of daily activities in COPD patients and healthy age…

Motor Abilities of Children with Clubfeet at Primary School Age.

Objective: This study aims to investigate, whether children with clubfeet are facing difficulties in daily life on activity*s and participation, two domains of the ICF, comparing to their age-mates without clubfeet.

Muscle ultrasonography: a potential new tool to diagnose and evaluate treatment in dermatomyositis and polymyositis

The aim of this study is to assess the diagnostic and monitoring properties of muscle US and to investigate if US is able to distinguish a myositis flare-up from a steroid-induced myopathy.

The development of secondary hyperalgesia after high frequency electrical stimulation (HFS) of the skin in patients with and without chronic postoperative pain after inguinal hernia repair.

To identify the mechanism(s) of pain in patients with chronic pain after inguinal hernia repair.

New ultrasound techniques in the detection of testicular adrenal rest tumours in children with congenital adrenal hyperplasia

To study the incidence of TART in children with congenital adrenal hyperplasia with new imaging techniques such as high frequency ultrasound and elastography

Smellprints in lung Cancer; the role of ENose in diagnosis and Treatment (SCENT):
part 4. Diagnostic value of the eNose in Head and Neck Cancer

The primary objective of this study is:to examine the difference in VOC pattern of exhaled air (breathprint) between patients with histology-confirmed diagnosis of head and neck squamous cell carcinoma (HNSCC) and healthy controls.The secondary…

Effects of postprandial hyperglycemia on aortic elasticity in impaired glucose tolerance and diabetes mellitus type 2

We aim to study the short-term effects of postprandial hyperglycemia in patients with impaired fasting glucose and in patients with T2DM on aortic stiffness as measured by PWV. Secondly, we study the effects of postprandial hyperglycemia on the…