161 results
COMT and/or PRODH polymorphisms are debt to cognitive deterioration in velocardiofacial syndrome.
By using a surgical safety checklist, the incidence of postoperative complications will decrease.
1. In Barrett Esophagus (BE), probe-based laser endomicroscopy (pCLE) provides better correlation with the histological diagnosis compared to detailed inspection with Narrow Band Imaging (NBI), reducing the high rate of false-positive findings with…
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We hypoothesize that the effect that a single dose of montelukast has on exercise induced bronchoconstriction correlates with the effect it has after 8 weeks of treatment.
The relative risk of developing macular edema in diabetics after cataract surgery is enhanced.
Chronic allograft nephropathy is the main cause of long-term renal transplant failure. The pathogenesis involves amongst others calcineurin inhibitors. We performed a multicenter randomized trial to study the effects of withdrawal of ciclosporin (…
Presence of postural instability and gait dissorder PIGD (gait disorders, balance impairment, falls, fal-related injuries and FOG) are an important and disabling feature of idiopathic Parkinson’s disease (PD) where the level of functional ability is…
Multiple Endocrine Neoplasia type 1 (MEN1) and Von Hippel-Lindau disease (VHL) are rare autosomal dominantly inherited disorders characterized by the occurrence of various tumors. Therefore, mutation carriers undergo regular screening (yearly for…
A slow and unpredictable deterioration of the capabilities of the older patient can lead to a vulnerable situation, often unnoticed by the caregiver. As a consequence, care is delayed and acute problems will arise that will need an immediate…
PHASE 1: 1. Identify the extent to which care management (as a competency) is implemented in the curriculum of postgraduate medical education in the Netherlands; 2. Evaluate stakeholders’ perceptions of the concept of care management (in medical…
In this observational trial we would like to study the possible correlation between the probe-drug dextromethrophan and tamoxifen pharmacokinetics. In case a good correlation is available, this might help in a stepwise development of truly…
The incidence of gastric cancer has been declining steadily since the 1930s, but it remains a major cause of cancer death in the Western world. The high mortality rate reflects the prevalence of advanced disease at presentation. The five-year…
Pregnancy rates will not differ between patients with a positive and negative result of the PCT.
To assess the current indications for URS and the treatment outcomes in terms of the stone free rate.
The purpose of the study is to conduct a randomised controlled trial with the training course 'Less stress through mindfulness' as an intervention to study the: 1. Effectiveness in terms of reduction of psychological symptoms (depressive…
Patients 12 months after Weilby procedure have less difficulties during daily life compared to patients after Burton Pellegrini procedure.
The application of the haemostatic device, ACF-matrix haemostat will reduce blood and fluid loss from the LIMA bed after CABG surgery.
This pilot study hypothesizes that ICG enhanced near-infrared fluorescence (NIRF) optical imaging enables the intra-operative detection of breast carcinoma in breast cancer patients.
The hypothesis to be tested is that the efficacy and toxicity of treatment with 90Y-ibritumomab tiuxetan meets the expectations as described in the protocol.