30 results
Objective: to investigate in vitro a relationship between plasma free haemoglobin and extracorporeal life support-related parameters such as pump flow, catheter selection, pump speed and pump heating. 1. Blood flow is positively related to plasma…
The primary objective of this study is to obtain clinical proof of principle that the Addition of a PgP/BCRP inhibitor increases CNS concentrations of tyrosine kinase inhibitors by inhibition of drug efflux transporter function in the blood brain…
Because of the high colorectal cancer (CRC) risk, Hodgkin lymphoma (HL) survivors should be offered colonoscopy screening, which has the potential to reduce CRC incidence and mortality. However, the diagnostic yield, cost-effectiveness and burden of…
1) FeNO, blood eosinophils and total IgE will have a moderate diagnostic accuracy to detect sputum eosinophilia in adult-onset asthma patients. 2) There will be differences in accuracy between sub-groups of patients.
This study tests the hypothesis that age has an effect on prefrontal brain activity, measured by fNIRS and EEG, during a cognitive paradigm assessing proactive response inhibition and working memory. The results of the fNIRS-EEG study will be…
To test wheter the Enose can differentiate between pneumonia (or exacerbation of COPD, asthma exacerbation or respiratoiry infection) by viral of bacterial infection.
Fentanyl is a strong opioïd and is highly lipophilic. Fentanyl pharmacokinetics are characterised by large inter- and inpatient differences, which may have serious consequences for the activity and toxicity profile of this drug. In this study we…
There is consensus that an endotracheal intubation procedure should be performed while the infant is adequately sedated. However, whether sedation should be given during the minimal invasive surfactant procedure is still unclear. So far, no studies…
It is expected that the urinary and serum level of intestinal fatty acid binding protein (I-FABP) and the urinary level of Claudin-3 have prognostic relevance for early identification of patients at risk for intestinal ischemia-related morbidity or…
Magnetic resonance imaging (MRI) is now the imaging modality of choice for many neurological and musculoskeletal conditions. In the past, implanted cardiac devices including pacemakers (PM) have been contraindicated by MRI scanner, due to the…
patients with diabetic cardiovascular autonomic neuropathy are more prone to hypotension during surgery and therefore require more inotropic/vaspressor medication perioperatively
We expect that when the developed checklist will be used in de diagnostic proces of children with developmental and/or behavioral disability, the use of pediatric care will be more efficiently used. Over and underdiagnoses of a causal somatic…
The effect of pulse rate on temporal resolution and speech intelligibility in cochlear implant users
CI pulse rate is known to affect temporal resolution and speech intelligibility. Based on literature it is hypothesized that low pulse rates decrease temporal resolution, but increase speech intelligibility.
The main hypothesis is that normo-ovulatory women with a deleterious BRCA mutation have lower levels of AMH compared to normal controls, with at least a difference of 0.90 ng/ml, suggesting an effect size of approximately five years in menopausal…
We hypothesize that group medical appointments will enhance adherence to treatment and self-efficacy in patients with sickle cell disease, as well as increase quality of life, and satisfaction with the treating physician and nurse. When performing…
The aims of the study are: 1) To investigate the effectiveness in diminishing behavior problems of Behavioral Parent Training Groningen (BPTG) for parents of children with an ASD and behavioral problems between 4 and 13 years of age in two formats…
The objective of this study is to describe a pharmacokinetic profile of total and unbound plasma concentrations ropivacaine, when used for local infiltration analgesia in total knee arthroplasty
- A new sensorbased gait analysis measurement as a simple and quick diagnostic/monitoring tool to evaluate joint status and changes in gait pattern in hemophilia patients. - Possibility to detect a disturbed gait pattern in clinically asymptomatic…
Delivery of a generic MBSR training to patients who visit a memory clinic with cognitive complaints, and who show no clinical signs of a cognitive disorder, is feasible.
This study primarily aims to explore changes in physical activity pattern and energy expenditure in head and neck cancer patients, during and after treatment with surgery with or without (chemo)radiation. The following primary null hypotheses will…