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The primary objective is to compare a composite endpoint of major CV events and all-cause death between control and intervention group.Secondary objectives are the comparison of patient-centered outcomes between the two groups.

Observational Dutch Young Symptomatic StrokE studY - Extended

To investigate the role of the immune system in the etiology and prognosis in an acute ischemic stroke (or TIA) in young stroke patients.

T-Cell Mediated Plaque Inflammation and Atherosclerosis in Stage III Melanoma Patients on (neo-)adjuvant Immune Checkpoint Inhibitors: a prospective matched cohort study

To investigate the effects of ICIs (anti-CTLA4, anti-PD1, combination anti-CTLA4/PD1) on vascular inflammation (PET-CT) in stage III melanoma patients. We hypothesize that the increase in vascular inflammation will be greater in the exposure group…

Cold as a therapeutic strategy to improve cardiovascular risk factors

This study will consist of three parts with three different main objectives:- Part 1 - Pilot study; Primary objective: To assess and compare thermal comfort upon wearing a cooling vest, based on exposed cooling packs versus…