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Tear biomarkers for Alzheimer's disease (AD) screening and diagnosis

To investigate whether tear biomarkers can differentiate between patients and controls, and between patient groups.

Clinical outcomes and cost-effectiveness of a diagnostic and treatment strategy of upfront CTCA plus selective non-invasive functional imaging compared with standard care in patients with chest pain and suspected coronary artery disease

This strategy will result in a reduction reduce the incidence of major adverse cardiovascular events (MACE) defined as death or non-fatal myocardial infarction and appear more efficient than care as usual.