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Understanding colchicine resistance in Familial Mediterranean Fever; exploring pathophysiological mechanisms and therapeutic options

The primary objective is to identify what causes colchicine resistance in FMF. Additionally, we will try to identify potential interventions to overcome resistance

A randomized, open-label, multicentric, two-arm pivotal trial of SonoCloud-9 combined with carboplatin (CBDCA) vs standard of care lomustine (CCNU) or temozolomide (TMZ) in patients undergoing planned resection for first recurrence glioblastoma

To evaluate and compare the survival outcome of patients with first recurrence of glioblastoma undergoing surgical debulking/resection followed by either implantation of the SC9 device and repeat BBB opening in association with carboplatin…