47 results
We aim to validate MRS with a cholinergic challenge as method to investigate muscarinic M1 receptor functioning. To investigate the relationship between the response to a muscarinic receptor antagonist with biperiden phMRI and [123I]IDEX SPECT…
Posner spatial cueing task will be used to investigate electrophysiological differences in brain oscillatory lateralization during attentional shifts in children with and without ADHD. We hypothesize that the observed difference in the ability to…
Primary Objective:The primary objective in the current trial is to use graph theory to examine how the organization of the functional brain network may be altered by the administration of methylphenidate. The main question we intend to answer in…
Primary objectives:To determine the exposure-response relationship of EVP-6124 over a range of plasma concentrations in a scopolamine-induced cognitive deficit model in healthy elderly subjects.Secundary objectives:To determine the exposure-response…
We aim to examine, in the impaired older population, whether a treatment using methylphenidate, a DA re-uptake inhibitor that enhances DA, improves attention and memory.
Primary :to evaluate the safety and tolerability of EVP-0962 after single and multiple ascending dose administrations in healthy subjectsSecondary :to determine the pharmacokinetic profile of single and multiple oral doses of EVP-0962 and to assess…
The main objective is to investigate the role of MRs in memory acquisition and recall during stress and non-stress conditions. Specifically, we are interested in two domains of memory, spatial and fear memory. Secondary objectives are to determine…
- to evaluate the safety and tolerability of a single oral dose of SCH 900229 administered to healthy adult volunteers- to characterize the pharmacokinetic (PK) profile of SCH 900229 in plasma of healthy adult volunteers after a single oral dose- to…
To study whether the administration of oxytocin leads to stronger empathic responses on 3 different empathy-related tasks compared to a placebo.
This study aims to determine the effects of acute coffee consumption compared to consumption of decaffeinated coffee on subjective fatigue and vitality ratings, neuropsychological performance and brain activity during working memory and learning…
The primary objective of this study is to evaluate the long-term maintenance of efficacy of SPD503 in childrenand adolescents (6-17 years) with attention-deficit/hyperactivity disorder (ADHD) who respond to an initial open-label,short-term treatment…
Objectives of the study: Project 1 - To assess early adaptive deficits in a multicentre cohort of mild to moderate TBI patients and their relation to outcome. Project 2 - Early intervention study of Cognitive Behavioural Therapy (CBT) to assess…
The current study aims to further our understanding of the relationship between baseline measures - such as impulsivity, working memory and social support - and the effects of enhancing dopamine (via methylphenidate administration) across a wide…
The principal objective of this study will be to critically evaluate if the fMRI-neurofeedback training is successful in reducing ADHD symptoms and improving cognitive functioning. Thus, the first goal is to show that ADHD patients are able to…
- To assess the safety and tolerability of escalating single and multiple IV doses of SAR228810 in AD patients- To evaluate the pharmacokinetic properties of SAR228810 in plasma and CSF after escalating single and multiple IV doses of SAR228810 in…
Primary: To compare the efficacy of aripiprazole with placebo in the suppression of tics in children and adolescents (7-17 years) with a diagnosis of Tourette*s Disorder. The primary efficacy measure is change from Baseline to endpoint (Week 8) on…
- To assess the safety and tolerability of escalating single and multiple IV doses of SAR228810 in AD patients- To evaluate the pharmacokinetic properties of SAR228810 in plasma and CSF after escalating single and multiple IVdoses of SAR228810 in AD…
Primary objective of the study: 1. To report on the effectmodification by age of MPH treatment on the outgrowth of the DA system using state-of-the-art Magnetic Resonance Imaging (MRI) techniquesSecondary objectives:1. To report on the…
1) To investigate if it is possibility to measure neural activation (CBF) in the DA brain stem nuclei and the functionally associated brain regions with ASL. 2) To investigate the effect of increased DA on activation in the DA system during resting…
Examine how unexpected reward and unexpected punishment affect working memory, that is, the ability to maintain information across time, update task-relevant information and ignore task-irrelevant information.Determine the extent to which…