Search for a trial

Bumetanide in Autism Medication and Biomarker study

The primary objective of the proposed study is to investigate whether bumetanide therapy indeed reduces autistic symptomatology. Important secondary goals of this project are to determine whether bumetanide will improve specific behavioral,…

*Working memory training in children with neuropsychiatric disorders and borderline intellectual functioning*

1. To investigate the efficacy of Cogmed working memory training in reducing behavioral symptoms in children with neuropsychiatric disorders and borderline intellectual functioning.2. To investigate whether WM training improves neurocognitive…

Effects of N-3 fatty acids (DHA and EPA) on cognitive control and associated brain activity in ADHD: A double-blind placebo controlled study

The objective of the present study is to investigate whether a diet rich in n-3 fatty acids (DHA/EPA) can improve brain activation patterns assiociated with cognitive control in children with ADHD .

Improving emotion recognition in children with Autism Spectrum Disorders (ASD) and Borderline Intellectual Functioning (BIF).

To test the hypothesis that The Transporters will show significant more improvement in contextual understanding of emotions and social functioning in children with ASD and BIF than a control intervention.

A 2-part randomized, three-period cross-over, placebo controlled, proof of mechanism study to investigate the effect of RO5285119 on vasopressin (AVP) pathway activation in healthy male subjects

Primary Objectives- To replicate AVP-induced inhibition of anterior cingulate cortex (ACC) activity and functional connectivity as measured by BOLD fMRI during a face matching task. - To assess the effect of RO5285119 in the modulation of AVP…

Bumetanide for the Autism Spectrum Clinical Effectiveness Trial

The primary objective of the study is to test the effectiveness of bumetanide across the whole spectrum of sensory processing disorders within ASD, ADHD and/or epilepsy. We also want to determine which subgroups (high/low IQ, comorbidities or not)…

Effectiveness of methylphenidate in children and adults with Smith Magenis syndrome and attention-deficit/hyperactivity disorder: An N-of-1 series

The primary objective is to determine the efficacy of methylphenidate on ADHD symptoms in Smith Magenis syndrome.The secondary objectives include the efficacy of methylphenidate on emotion dysregulation and specific goals that are important to the…

An adaptive, randomized, double-blind, placebo-controlled, single and multiple ascending dose study to examine the safety, tolerability, pharmacokinetics, pharmacodynamics and food effect of RGH-338 in healthy male volunteers.

To investigate the safety and tolerability, and to characterise the pharmacokinetics (PK) of RGH-338 in healthy subjects

Multicentre, randomised, double-blinded, placebo-controlled trial of efficacy of amoxicilline/clavulanic acid in patients affected by tic disorder colonized by GAS. No-proft stidy.

This study is an extension of the European Multicenter Tics in Children Studies (EMTICS) Course study for which a separate study protocol exists; its aim is to verify the efficacy of GAS colonization treatment on tic symptoms in term of severity.…