17 results
To investigate whether bowel relaxation, induced by administration of hyoscine N-butylbromide, improves the detection, removal and colllection of lcolonic polyps during colonoscopy
Primary Objective: To evaluate whether a single intravenous alfentanil bolus (7.5 mcg/kg) has a clinically significant analgesic effect in clinical patients who undergo an elective CT-colonography compared to placebo. We have defined a clinically…
The primary objective is to generate genome-wide miRNA profiles of patient material (tissue samples and blood). The secondary objectives are to compare miRNA expression profiles to investigate what role differences in miRNA expression have in the…
1) Identify chemopreventive properties of mesalazine in patients at high risk of recurrent (nonfamilial) colorectal adenomas by evaluating the effect of treatment on apoptosis and proliferation in histologically normal sigmoid and rectal mucosa…
Study the risk of colorectal adenomas in patients detected with duodenal adenomas.
1. To determine the prevalence of gastric fundic gland polyps in patients undergoing routine upper gastrointestinal endoscopy2. To determine the prevalence of dysplasia in these gastric fundic gland polyps3. To determine the prevalence of gastritis…
Assessment of the adenoma detection rate at colonoscopy using :A: Standard colonoscope B: High Definition colonoscope C: High Definition colonoscope with surface enhancementD: High Definition colonoscope with surface enhancement and Colon Mode
In the Netherlands, approximately 500 patients with FAP have been recognized, who are at high risk for developing duodenal carcinoma. Better insights in the pathogenesis of duodenal cancer and development of chemoprevention strategies are of pivotal…
In a randomized trial we will compare the cost-effectiveness and cost-utility of TEM and EMR for the resection of large rectal adenomas.
In the present study the effects of the colonic administration of butyrate on portal, hepatic, mesenteric venous and arterial SCFA concentrations will be studied in patients undergoing major upper abdominal surgery. The aim is to clarify the…
To assess the skeletal health of FAP patients.
The aim of this study is to compare the additional diagnostic yield (adenoma detection rate) of G-EYE colonoscopy with that of standard high definition colonoscopy.
Identify DNA methylation markers suitable for sensitive and specific plasma-based detection of advanced colorectal adenomas.
Primary objectives:The primary objectives are to evaluate the feasibility of oral administration of bevacizumab-800CW and cetuximab-800CW for detection of neoplasia in BE patients compared to HD-WLE to shorten the qFME procedure and test whether…
1. To investigate the optimal time interval for colonoscopy surveillance in patients with low-risk and high-risk adenomas (EPoS I trial and EPoS II trial); 2. To evaluate the yield of surveillance in patients with clinically relevant serrated polyps…
To compare L-MILP with R-MILP for benign and pre-malignant lesions of the pancreas in high-volume centers, regarding:1. Peri- and postoperative outcomes in terms of COMPOS-panc left score, for non-inferiority2. Total hospital-related costs, for…
Primary:1) To compare OS in subjects with squamous cell carcinoma of the Esophagus.2) To compare OS in subjects with PD-L1 Combined Positive Score (CPS)*10%3) To compare OS in all subjectsSecondary:1) To evaluate the progression free survival (PFS)…