20 results
The primary objective of CDfuture is to provide duodenal biopsies of patients with and without CD, and venous blood samples, to continue CD research as described above.
Evaluation of a multidisciplinary ICT SMS for children with CD.
1) Prevalence of celiac disease in a Dutch cohort of adult type 1 diabetes patients. 2) Investigation of the long term complications of type 1 diabetes patients with concomitant celiac disease
Optimization of the supplementation of vitamins and minerals1. In patients who received a gastric banding for treatment for their morbid obesitya. Reduction of iron deficiencyb. Reduction of Vitamin B12 deficiencyc. Reduced Vitamin D deficiency2. In…
The aim of this randomized controlled trial is to determine the affect of screening on the Gastrointestinal symptoms (GIS) and Health Related Quality of Life (HRQL) in asymptomatic first degree relatives of CD patients. On the basis of the results,…
1. Development of a prevention strategy for CD in children from high risk families for the disease by induction of oral tolerance to gluten;2. Identification of the immunological mechanisms involved in initiating the aberrant response to gluten…
The effect of a high-fat breakfast on intestinal permeability will be examined in lean and obese men to see if a fat load can induce increased intestinal permeability and it is a feasible challenge test to investigate effects of foods / ingredients…
The primary oblective of the study is to elucidate all molecular mechanisms leading to coeliac disease.In order to establish the scientific basis for the development of improved diagnostics, novel therapies and safer foods for patients, in the CDC:…
1. A better understanding of the apraglutide dose/concentration-effect relationship;2. A better understanding of duration of effect (apraglutide kinetics in relation to citrulline kinetics).
To investigate whether adjusting the length of the BP-limb of the OAGB based on measured total small bowel length leads to more weight loss, resolution of co-morbidities with less development of micronutrient deficiencies and bowel movements…
With this study, we aim to gain insight in the influence of dietary oxalate on urinary oxalate levels by quantification of the intestinal oxalate absorption in patients with recurrent idiopathic calcium oxalate stones, primary hyperoxaluria, and…
5.1 Primary ObjectiveTo confirm the efficacy of glepaglutide in reducing PS volume in SBS patients.5.2 Secondary ObjectivesTo evaluate the efficacy of glepaglutide on other efficacy endpoints in patients with SBS.To evaluate the safety and…
Primary Objective: Proof of safety and tolerability of home parenteral nutrition (HPN) with an Omega-3 fatty acid enriched MCT/LCT lipid emulsion in adult patients with chronic intestinal failure (CIF) in need of long-term HPNSecondary Objectives:…
This study has been transitioned to CTIS with ID 2024-513374-22-00 check the CTIS register for the current data. 5.1 Primary ObjectiveTo evaluate the long-term safety of glepaglutide treatment in SBS patients.5.2 Secondary ObjectivesTo evaluate the…
Primary objective: To assess the efficacy of treatment with ELGN-2112 as compared to placebo on intestinal malabsorption in preterm infants as measured by the time to full enteral feeding. Defined as first day of reaching three consecutive days of…
Primary objective: To compare the safety of treatment with ELGN-2112 to placebo in preterm infants born less than 26 weeks GA and IUGR infants<3rd percentile * born at 26-32 weeks GA. * According to Fenton preterm growth chart. Secondary…
Primary objective: to objectify the influence of Roux-en-y gastric bypass surgery on the prevalence of lactose intolerance / malabsorption.Secondary objective: To determine the usability of the lactose hydrogen breath test, the lactose tolerance…
The STEM study presented here aims to increase our knowledge of the most common intestinal, gastric and liver epithelial diseases with the ultimate goal to treat these disorders. Particularly, children that have severe malfunction of their…
The primary objective is to evaluate the efficacy and safety of NTRA-9620 compared with placebo when added to standard of care (SOC) in pediatric subjects (aged 28 weeks post-menstrual age to 52 weeks chronological age) with SBS within 4 months from…
To assess the efficacy and safety of 2 dose levels of NTRA-2112 on intestinal malabsorption in preterm infants as compared to placebo.The sub-study aims to determine whether NTRA-2112 in own mother's milk, donor human milk or preterm formula…