Search for a trial

Single Blind Randomized Phase III Trial to Investigate the Benefit of a Focal Lesion Ablative Microboost in Prostate Cancer

- Primary study objective: To demonstrate the superiority of the ablative microboost dose schedule regarding 5-year biochemical no evidence of disease rate compared to the current standard of care.- Secondary study objectives: Establish and compare…

Outcome study on gender identity, sexual functioning and psychological well being in patients with a disorder of sexual differentiation

In this study the prevalence and kind of sexual and psychosexual problems will be assessed. Psychological well being is studied as well

The effect of position (sit/stand up vs supine position) on urge sensation in volunteers and in patients with overactive bladder syndrome

The primary objective of this experiment is to describe via an observational study the relation between conditions of sitting/standing up versus laying down in terms of bladder sensation in both volunteers and patients with OAB. We also want to…

T cell homeostasis after ATG induced lymphocytopenia in renal transplant patients; studied through in vivo 2H2O labeling

To get more insight into the T cell homeostasis in lymfocytopenic, ATG treated patients and normocytopenic patients treated with standard maintenance immunosuppressive drug therapy.

Validation and standardization of the measurement of pelvic floor dysfunction with the MAPLE-probe

A. Determine the placement of the Maple-probe in relation to the anatomy of the pelvic floor musculature.B. Determine the normal rest tone of the pelvic floor musculatureC. Determine the normal activity of the pelvic floor musculatureD. Determine…

A randomised controlled trail comparing the TVT-O® with the Ajust® as primary surgical treatment of female stress urinary incontinence.

Objective: Primary Objective: to compare the immediate and postoperative pain (up to 6 weeks) between the Ajust® and TVT-O® proceduresSecondary Objective(s): 1. Objective cure of the SUI at 6 and 12 months follow up2. Subjective cure and improvement…

Evaluation of the pelvic floor patients with Pelvic Organ Prolaps (POP) and controls, using dynamic MRI and Diffusion Tensor Imaging (DTI).

In this study we aim to evaluate pelvic floor structures in both POP patients and controls with the use of different anatomical landmarks and reference lines in non-invasive dynamic MRI. Additionally we propose to evaluate the feasibility of DTI in…

A Phase III, Randomised, Double-blind Study to Assess the Efficacy and Safety of 10 mg ZD4054 versus Placebo in Patients with Hormone-resistant Prostate Cancer and Bone Metastasis who are Pain Free or Mildly Symptomatic

To Assess the Efficacy and Safety of 10 mg ZD4054 versus Placebo in Patients with Hormone-resistant Prostate Cancer and Bone Metastasis who are Pain Free or Mildly Symptomatic

The multiparameter MLC-CFSE test to predict T cell-allo-immune reactivity in renal transplant recipients.

To select T cell properties intrinsic to the transplant recipient, which can discriminate between patients who will likely experience acute cellular rejection episodes from those who don*t.

A Phase III, Randomised, Placebo-controlled, Double-blind Study to Assess the Efficacy and Safety of Once-daily Orally Administered ZD4054 10 mg in Non-metastatic Hormone-resistant Prostate Cancer Patients

To Assess the Efficacy and Safety of Once-daily Orally Administered ZD4054 10 mg in Non-metastatic Hormone-resistant Prostate Cancer Patients compared to placebo.

A Phase 3, Randomized, Efficacy and Safety Study of Enzalutamide Plus
Leuprolide, Enzalutamide Monotherapy, and Placebo Plus Leuprolide in Men
With High-Risk Nonmetastatic Prostate Cancer Progressing After Definitive
Therapy.

This study has been transitioned to CTIS with ID 2024-513521-23-00 check the CTIS register for the current data. All efficacy and safety objectives will compare enzalutamide plus leuprolide and enzalutamide monotherapyversus placebo plus leuprolide.

SUPERvised three-month exercise program in MEN with Prostate cAncer Receiving androgen-deprivaTioN thERapy

To examine the impact of a supervised training program on disease-related quality of life and physical fitness in patient with advanced prostate cancer compared to usual care.

PROSPEC study; PROstate cancer follow-up care in Secondary and Primary hEalth Care

We hypothesize that the follow-up and aftercare of prostate cancer in the Netherlands can be led by the GP. We hypothesize that GP-led recurrence detection programme leads to at least equal detection of recurrences as the current follow-up in…

Two-fraction Ultra-hypofractionated Radiotherapy with Focal Boost for low- and intermediate risk, localized prostate cancer (TURBO):phase II, randomized controlled clinical trial

To assess non-inferiority of treating patients with localized, intermediate risk prostate cancer in two fractions of 12 Gray (Gy) with a boost to the gross tumor volume of 13.5 Gy per fraction in 8 days, as compared to standard care (36.25 Gy in…

Long-term follow-up of the offspring born to mothers with a solid organ transplant.

The primary aim of the study is to assess the overall health of offspring born to a mother with solid organ transplantation, and to identify possible pre- and perinatal risks for diseases later in life. In addition, we would like to collect and…