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A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Evaluate
the Efficacy and Safety of AMG 334 in Migraine Prevention

To evaluate the effect of AMG 334 compared to placebo on the change from baseline in mean monthly migraine days, in subjects with episodic migraine.hypothesis: In subjects with episodic migraine, AMG 334 has a greater reduction from baseline in mean…

Cardiovascular Riskprofile in Women: Microvascular Status

To gain further insight into the interaction and possibly shared pathophysiological mechanisms of female-specific cardiovascular risk factors and events we will quantify white matter hyperintensities on brain MRI and assess endothelial function in…

An explorative prospective observational case-control pilot of EEG registration of cortical spreading depression in patients aged 4 years or older, with an acute migraine attack admitted at the headache outpatient service of Medisch Spectrum Twente

Primary Objective: To measure cortical spreading depression with full-band EEG during the migraine attack at patients aged 4 years or older. Secondary Objective(s): -To explore (additional) signal analysis techniques for detecting CSDs or infra slow…

Trigeminovascular effects of propranolol in migraine treatment

To determine the mechanism of action of propranolol in the prophylactic treatment of migraine.

Bilateral vs. unilateral transcranial magnetic stimulation of the primary motor cortex to treat chronic orofacial pain: a pilot study with a randomized controlled design

In 2016, Henssen et al. discuss that orofacial pain may be conducted in a bilateral fashion, inducing activation of both thalami [1]. For this reason, bilateral stimulation of the motor cortex is thought to induce a stronger analgesic effect…

A randomized, multicentre, double-blind, parallel, sham-controlled study of the gammaCore®, a non-invasive neurostimulator device for the acute relief of episodic and chronic cluster headache.

Primary Objective:The primary objective is to compare the pain free rates at 15 minutes following the use of GammaCore® with that of a sham device, for acute treatment of cluster headache attacks.Secondary Objectives:The secondary objectives will…

Occipital nerve stimulation in patients with medically intractable chronic cluster headache:
A PET study

The focus of this present study will be to better understand the mechanism of ONS in MICCH. The primary objective of this study is to investigate the putative differences in rCBF at 6 months follow-up compared to baseline between responders of ONS…

Sumatriptan non-responders: evaluation of a possible biomarker

To find a simple test to explain non-responsiveness to sumatriptan in a proportion of patients with migraine.

Chronification and reversibility in migraine (CHARM)

1. We want to study the success rate of OAHM withdrawal in patients with chronic migraine related to support by a headache nurse, and onabotulinum toxin A injections during the withdrawal period, and the influence of comorbid depression.2. We want…

The RVCL-ID study - Identifying biomarkers and disease stages of Retinal Vasculopathy with Cerebral Leukodystrophy (RVCL), a monogenic vascular migraine model

1. To identify presymptomatic and symptomatic profiles including (early) disease stages and early biomarkers of disease progression and to elucidate pathophysiological mechanisms, we will investigate RVCL patients at different ages (both symptomatic…

Intracranial pressure variability in migraine;
A prospective study to evaluate changes in intracranial pressure during different migraine attack phases

ObjectivesOur main hypothesis is that ICP shows a dynamic profile over the course of different attack phases in migraine. Therefore, we aim to detect dynamic changes in ICP in relation to different phases of the migraine attack. In concreto, the…

A double-blind, placebo controlled, randomized study to evaluate the safety, tolerability, pharmacokinetic profile and cytochrome P450 interaction potential of single and multiple doses of Tonabersat over the dose range of 240 mg to 480 mg in healthy adult subjects.

to assess the single-dose safety, tolerability and pharmacokinetic profile of (6) individual doses of tonabersat ranging from 160 mg to 480 mg (or to dose-limiting toxicity (DLT)) in healthy subjects under the fasted or fed conditionsto assess the…

Capsaicin induced neurogenic inflammation of the skin: influence of migraine and estrogen level

- Measurement of the flow response to dermal application of capsaicin in the trigeminal nerve region in women with and without migraine.- Measurement of the flow response to dermal application of capsaicin in the trigeminal nerve region at various…

Trigeminal sensitivity and hormonal fluctuations during the onset of migraine;
A biochemical and neurophysiologic study in male migraineurs

Objectivesi)) To study whether reproductive hormones play a role in migraine susceptibility in malemigraine patients; ii) to study functionality of the trigeminal system prospectively duringinterictal and premonitory phases of the migraine attack (…

A PHASE 1, RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND, MULTIPLE DOSE, PARALLEL ARM STUDY TO EVALUATE THE EFFECT OFMEAL TIMING AND FOOD- VERSUS THE FASTED STATE ON THE SAFETY, TOLERABILITY AND PHARMACOKINETICS OF REPETITIVE DAILY DOSES OF TONABERSAT (USL260) IN HEALTHY SUBJECTS

The purpose of the study is to investigate how safe the compound USL260 is and how well the compound USL260 is tolerated under fasting and fed conditions. The study will also investigate how quickly and to what extent the compound USL260 is absorbed…

Lateral C1-2 Joint Pulsed Radiofrequency Application in the treatment of Cervicogenic Headache

The primary objective in this study is to compare the effectiveness of lateral C1-2 pulsed radiofrequency application (LPRF) in comparison with conventional C3-5 facet denervation (MBRF) in patients with clinically defined cervicogenic headache.

A Worldwide, Randomized, Double Blind, Placebo-Controlled, Parallel Group Clinical Trial to Evaluate the Safety and Efficacy of Rizatriptan for the Acute Treatment of Migraine in Children and Adolescents

The objective of this study is to test the safety of the research study drug, MK-0462 (rizatriptan) and to test the ability of study drug to relieve or reduce migraine for the study population.

Functionality of the Migraine Brain; a prospective fMRI study

Objectives- We want to study time-dependent activation in neuronal networks related to pain, vigilance and autonomic functioning in migraine patients during different migraine phases (including premonitory phase);- We want to correlate these changes…

THE EFFECT OF PROBIOTICS ON
THE FREQUENCY AND INTENSITY OF MIGRAINE ATTACKS
AND INTESTINAL PERMEABILITY - A PLACEBO-CONTROLLED TRIAL

To test whether probiotics, as adjuvant therapy, can reduce incidence and severity of migraine attacks by reducing intestinal permeability.

The RVCL-MRI study: neuroimaging findings and cerebrovascular reactivity in preclinical and clinical disease stages of Retinal Vasculopathy with Cerebral Leukodystrophy (RVCL), in migraine patients and healthy controls.

1. To assess neuroimaging hallmarks of RVCL disease stages;2. To evaluate cerebrovascular reactivity as a biomarker of endothelial (dys)function in RVCL patients, in migraine patients and healthy controls;3. To identify shared pathophysiological…