27 results
To evaluate the safety and efficacy of lucinactant for inhalation, in comparison to nasal continuous positive airway pressure (nCPAP) alone, inpreterm neonates with RDS, as assessed by the time to, and incidence of, respiratory failure and/or death…
The primary objective of this study will be to evaluate the cardiac adaptation due to hemodynamic changes in monochorionic twin pregnancies complicated by TTTS and sIUGR, by evaluating the size and the growth pattern of the pulmonary artery and the…
To investigate the direct effect of caffeine on the respiratory effort of the preterm infant at birth.
Main question: What is the lung function of late preterm births compared with children born at term at age 12? Sub-questions: - Which respiratory symptoms in late preterm infants at age 12?
To study whether microcirculatory perfusion is improved by ECMO. Perfusion will be studied before & after ECMO start, during ECMO weaning and before & after ECMO stop. To study the precictive value of perfusion and its correlation…
The aim of this study is to test the hypothesis that using nasal tube as interface during resuscitation/stabilisation of preterm infants at birth is more effective compared to mask.
Does the use of NIPPV in ELBW infants (<30 wks of GA and BW<1000gr) requiring non-intubated respiratory support in a Level III perinatal center increase the rate of survival without BPD when compared to nCPAP.
Primary objective- Survival without BPD at 36 weeks gestational age (GA)Secondary objectives- Neurodevelopment at a corrected age of 18-22 months- Adverse treatment effects- Mortality at 36 weeks gestational age- BPD incidence at 36 weeks…
Aim of total study:Diagnosing all components of RS in an objective mannerAim of present substudy:Increasing the reliability and decreasing the burden of the method with which glossoptosis can be determined in newborns with RS
The main objective is to improve exercise tolerance. Secondary objectives are: 1) improvement of motor function development, daily physical activity, quality of life, self perception of motor competence, and participation; 2) evaluation of cost…
Primary Objectives: The primary objectives of this study are to evaluate the efficacy and safety of IV sildenafil when added to iNO for the treatment of neonates with PPHN or hypoxic respiratory failure and at risk for PPHN. Secondary Objectives: *…
The first aim of this study is to obtain insight in the physical fitness of ex-preterms. The second aim is to study the influence of the daily activity pattern of the children on physical fitness. The third aim is to study the attitude of parents…
To compare the occurrence of significant mask leak when using a nasal mask versus a facemask in preterm infants needing positive pressure ventilation.
Primary Objective: To identify new markers in BPD, in particular in sphingolipid- and oxylipin profiles in tracheal aspirates.Secondary Objective(s): To predict the development of BPD in preterm infants by the use of metabolomic analysis of the…
Is a higher dose of aerosolised salbutamol as a treatment for preterm infants suspected for developing BPD more effective than a lower dose on short-term clinical effects?
The aim of this study is to develop a safe and fast MRI protocol for the imaging of neonatal and pediatric BPD patients. This METC application addresses the first part of the MRI- BPD project: *Ventilation, Inflammation, perfusion and structure in…
Primary ObjectivesPart A:To determine the pharmacokinetics (PK) of intramuscular (IM)administrations of REGN2222Part B:To demonstrate the efficacy of REGN2222 in preventing medicallyattended respiratory syncytial virus (RSV) infections (subjects…
The objective of this study is to analyse the hypothesis that intravenous milrinone used in conjunction with iNO results in the reduction in the time on iNO therapy and the time spent on invasive ventilation in infants * 34 weeks gestation and *…
Primary objective: Part A: MR cardiopulmonary exercise protocol validation: To validate the protocol of the CMR-ergometer against conventional ergometers in young healthy adultsPart B: CMR exercise study To examine cardiorespiratory structure and…
To compare the effect of two automated oxygen controllers (Oxygenie and CLiO2) on time spent within oxygen target range in preterm infants.