Search for a trial

A Randomized, Comparative Trial of Two Posterior Lamellar Keratoplasty Techniques.
Ultrathin Descemet Stripping Automated Endothelial Keratoplasty (UTDSAEK) versus Descemet Membrane Endothelial Keratoplasty (DMEK).

To demonstrate that DMEK is superior to DSAEK with respect to VA.

Feedback Informed Treatment in child- and adolescent psychiatry. A randomized cluster controlled Intervention study

Objective: To test the hypotheses that Feedback Informed Treatment together with treatment as usual will show significant more improvement than treatment as usual alone.

Screening and treatment of psychological distress in colorectal cancer with metastasized disease: the TES-trial

We have developed the TES program, which involves Targeted selection and Enhanced care, delivered on the basis of Stepped care (TES). The primary study aim is to evaluate the effectiveness of the TES-program compared to usual care in reducing…

Societal participation with Boston Psychiatric Rehabilitation for
patients with severe mental illness: a cost effectiveness study

The main objective of the study is to gain insight into the cost-effectiveness of BPR compared to care as usual (CAU) for patients withSMI who have a wish for change in their societal participation. Research questions:1. Is BPR (cost-)effective…

ENdometrial cancer SURvivors' follow-up carE (ENSURE): Less is more? Randomized controlled trial to evaluate patient satisfaction and cost-effectiveness of a reduced follow-up schedule

The aim of this study is to compare a reduced follow-up schedule of 4 visits among low-risk, early-stage endometrial cancer survivors, with the schedule according to the current Dutch guideline that includes 10 to 13 visits, on:Primary outcomes:1.…

Patient controlled analgesia i.v. with morphine versus continuous epidural analgesia with bupivacaïne and sufentanil as pain relief after caesarean section.

We would like to research wether there is a difference in time of mobilization between women getting iv PCA with Morphine (PCA)as opposed to women getting continuous epidural analgesia (CEA)with bupivacaine and sufentanil.We expect that the PCA will…

eVita COPD; Patient Centered Care through eHealth Solutions

The main aim is to investigate clinical effects of different implementation methods of online supported self-management for COPD patients in primary care. Secondary objectives include effects on well-being, health care use and actual use of the…

The SO-HIP study,
Effectiveness of sensor monitoring in an occupational therapy rehabilitation program for older persons after hip fracture: design of a three-arm stepped wedge cluster randomized trial

The primary objective is to study the effect of sensor monitoring embedded in an OT rehabilitation program for older persons after hip fracture on recovery of daily functioning, 6 months after the start of rehabilitation, as compared to coaching by…

Erasmus MC Care Innovation for a healthy pregnancy. Efficacy of "Smarter Pregnant", an interactive food and lifestyle program on the mobile phone.

Investigate whether the "Smarter Pregnant" intervention in comparison with four screenings with food- and lifestyle advising leads to an improvement in unhealthy food habits (vegetables, fruit, folic acid use) after 24 weeks intervention,…

HOMERUN
Initiation of HOme MEchanical ventilation at home in a selective group of patients with chronic hypercapnic Respiratory failUre in the Netherlands

Patients with chronic respiratory failure currently start their ventilatory support in hospital as stated in national guideline. However, as these patients are severely disabled, a stay at the hospital for several days is experienced by many as very…

Distractibility in ADHD associated with reduced ability to modulate alpha band oscillations in attentional tasks

Posner spatial cueing task will be used to investigate electrophysiological differences in brain oscillatory lateralization during attentional shifts in children with and without ADHD. We hypothesize that the observed difference in the ability to…

Implementing Self management using eHealth for monitoring and management after Catheter ablation in the treatment of Atrial fibrillatioN.
A study on the diagnostic accuracy and the effects of eHealth rhythm monitoring on patient related outcomes, clinical management and health outcomes.

Optimise post PVI management using ambulant continuous patient-driven eHealth monitoring after catheter ablation in the treatment of atrial fibrillation.Primary Objective:1) Determine the effect of eHealth on clinical management, outcomes and…

Closing the preventive care chain for overweight children: evaluation of the implementation of an integrated, locally aligned approach, enforcing primary care.

Get insight in the implementation and effectiveness of the integrated preventive care chain for overweight children in 's-Hertogenbosch. With the results we can optimize the support for overweight children and their parents. .

Drug use Reconsidered in the Elderly using goal Attainment scales during Medication Review - The DREAMeR-study

To investigate whether a clinical medication review, focused on the perceived hindering complaints and personal wishes of the patients regarding their medication, improves health-related quality of life of older persons aged 70 years or older using…

Executive and social functioning in early- and continuously-treated patients with PKU: A follow-up study 10 years later

The main objective of this study is to examine the executive, social-cognitive, and social functioning and behaviour of 7-30 year old PKU patients in relation to history of treatment and treatment adherence. It is expected that there will be…

Group rehabilitation for renal patients

The purpose of GRN-study is: 1. to determine the long-term effectiveness of a 12 weeks lasting physical exercise training program. 2. to determine the costeffectiveness of the 12 weeks lasting physical exercise training program. In aim of the GRN-…

Pre-pain rehabilitation (PREPARE) treatment in chronic pain: a randomized controlled trial (RCT)

1. What is the effectiveness of MIP (MI-based pre-treatment) compared to UC (usual care) on the level of participation and treatment drop-out in patients with chronic non-specific musculoskeletal pain following pain rehabilitation?2. What is the…

Integrated Overactive Bladder Clinical Trial in clinical practice III

Primary objectives of INTACT III are:1) to prospectively compare the efficacy of Sacral Nerve Stimulation (SNS) with BOTOX® 100 U related to the Patient Perception of Bladder Condition (PPBC) questionnaire (Coyne 2006) and the reduction of urinary…

Remifentanil use for procedural sedation and analgesia in the emergency department

Answering the following questions:1. Main question: Is remifentanil a usefull medication for PSA in the emergency department?2. What is the recovery time of the patient when using fentanyl / propofol / remifentanil (time between last gift PSA…

Psychosexual consequences of risk-reducing salpingo-oophorectomy in BRCA1/2 mutation carriers.

Primary objective The primary objective is to examine the effect of a MBSR intervention on the menopause-specific quality of life in BRCA1/2 mutation carriers who experience RRSO-induced menopausal complaints. Secondary objectiveThe secondary…