133 results
To evaluate image quality and accuracy of detection of perfusion defects associated with pulmonary pathology on iodine maps of the lung that are created by two different CT techniques: 1. A standard of care CTPA with DECT and 2. A new technique that…
Objective 1: To prospectively evaluate the utility of C-FLOW monitor to examine status of regional CBF and reperfusion in patients presenting with acute anterior circulation ischemic stroke syndrome. Objective 2: To assess the feasibility,…
Frequency of PNH in a selection of patients with DVT. In several publications PNH has been described especially in patients with DVT and younger than 30 years of age and/or with DVT on unusual places.
Main study objective of this study is:To evaluate whether the 320-detector volumetric CT technology can replace carotid duplex scanning and TEE in the diagnostic workup in TIA/IS patients. Specific aims of this main study objective are:1. To assess…
The main aim is to investigate clinical effects of different implementation methods of online supported self-management for thrombosis patients in primary care. Secondary objectives include well-being, health care use and actual use of the portal.…
The goal is to investigate wether a PNH clone could be the cause of an unexplained thrombosis. In the population of patients with unexplained thrombosis a PNH clone may be the cause.The goal is to investigate whether the prevalence of PNH clones is…
See chapter 'objectives' of study protocol (page 12)
To determine the within and between variability of pharmacokinetic (PK) profiles in patients treated with DOACs in daily practice
In this study, we will assess the reproducibility of the observed dose-dependent inhibiting effect of CK on platelet aggregation.
The primary efficacy objective is to evaluate whether LMWH is superior to VKAs in the long-term treatment of symptomatic VTE in cancer patients who completed 6 to 12 months of anticoagulant treatment. Two aspects are important: the efficacy with…
The main objective is to determine the effect of different anticoagulant and procoagulant agents on thrombin generation in whole blood and compare it to the effect on thrombin generation in PPP and PRP at different tissue factor concentrations. In…
Choosing the most suitable laboratory test and setting up a gold standard test to measure dabigatran. Additionally, determining maximal and minimal concentrations of the drug.
1. Determine the relationship between periodontitis and HIV-related immune activation and hypercoagulability.2. Explore the role of oral microbiota as effect modificator of the relationship between periodontitis and immune activation in HIV-infected…
The aim of this research is to improve the understanding of the coagulation system through a detailed characterization and quantification of biosynthesis and expression of several coagulation proteins in BOECs. The data obtained in the study will be…
To investigate the potential of an interaction between 4 mg/kg and 16 mg/kg sugammadex and enoxaparin or UFH on anticoagulant activity in young healthy male volunteers.
There is no formal primary research hypothesis to be statistically tested. The purpose of this study is to evaluate the pharmacokinetics, the pharmacodynamics, the safety profile and tolerability following multiple oral doses of apixaban in…
Before embarking on a study using MRDTI as sole test to manage clinically suspected UE-DVT, we need to perform a study to determine whether the test has the potential to be useful in patients with suspected UE-DVT. This study has the objective to…
Primary objective:To determine the individual cardiovascular risk profile, using validated risk score screening methodologies (Framingham, PROCAM, Reynolds Risk Score and SCORE) in patients with VTE to evaluate how many patients are at risk for…
The primary objective of this study is to establish a panel of markers that can be used for further research into the understanding of the pathogenesis of PTS.
To evaluate the prevalence of gastrointestinal ischemia in patients with acute and chronic non-cirrhotic, non-malignant PVT.