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Registry of the treatment of primary insufficiency of the great saphenous vein with a diameter >/= 12 mm, antero-lateral branches, or great saphenous vein insufficiency below the knee with mechano-chemical endovenous ablation (MOCA)

The goal of this registry study is to provide insight in the safety and efficacy of treatment with MOCA for primary insufficiency of the GSV with a diameter >/=12mm, insufficient antero-lateral branches (<12 mm) and insifficincy of the…

Endovenous laser ablation versus mechano-chemical endovenous ablation in the treatment of great saphenous incompetence: a multicentric, randomized controlled trial

The Clari-laser study is designed to evaluate the following questions: 1. What is the succes rate of MECEA versus EVLA on short and long term? 2. Are the results after treatment both clinically and technically comparable? 3. What are the per-and…

Protocol CV185074: evaluation of multiple dose pharmacokinetics and pharmacodynamics of apixaban and rivaroxaban in healthy subjects

Primary:- to assess the multiple-dose pharmacokinetics of apixaban and rivaroxaban - to compare plasma concentration peak to trough ratio (Cmax/Cmin) of rivaroxaban to apixaban Secondary:- to assess the multiple dose pharmacodynamics (anti-Factor Xa…

Comparison of costs and patient reported outcomes of endovenous techniques in the treatment of incompetent saphenous veins: A single center, double blinded, randomized controlled trial

We want to investigate the patient satisfaction after both treatments and differentiation in direct costs between the radiofrequency ablation (by VNUS closureFAST) and treatment with the radial fiber 1470 nm endolaser. We want to compare both…

A randomized controlled multicenter trial comparing modern great saphenous vein stripping with crossectomy, with modern great saphenous vein stripping without crossectomy and radiofrequency ablation for primary great saphenous vein incompetence (STRIP trial).

To date, all studies evaluating minimally invasive interventions for treatment of venous insufficiency of the GSV have been comparing the techniques to the traditional method of stripping (under spinal or general anesthesia, without using duplex…

Histopathological study of mechanochemical endovenous ablation of the great saphenous vein

The aim of this study is the histopathological analysis of venous injury using mechanochemical endovenous ablation

European Observational Study of the Sapheon* Closure System for the Definitive Treatment of Incompetent Great Saphenous Veins: A Prospective Single Arm Multicenter Clinical Observational Study

5.1 Study ObjectivesThe primary objective for this clinical observational study is to assess the role of the Sapheon Closure System in closure of incompetent great saphenous veins in a routine clinical setting.5.2 Study HypothesisThis is an…

Parva II Trial: Randomized unicentre trial of re-crossectomy vs (repeated) ultrasound guided foam sclerotherapy of recurrence after crossectomy of the small saphenous vein

To compare the success rate and the occurrence of complications of re-crossectomy and (repeated) UGFS for the treatment of recurrence of the SSV for a period of 5 years.

A comparison of two anesthetic techniques for VNUS closureFAST procedure: local or locoregional

This study aims to show by which technique the patient feels the least pain. It is also designed to show which advantages and disadvantages are linked to the abovementioned forms of anesthesia and if there are differences in postoperative pain…

Minimal invasive treatment of varicose veins

Comparing the gold standard of surgical stripping with the minimal invasive treatment options: laser and VNUS (radiofrequency ablation)

Five year follow up of duplex investigations in young patients with a history of suspect venous disorders

Follow up of 38 patients who had a duplex investigation in the past when they were 18 years old or younger.