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A single-center, open-label study to evaluate the absorption, distribution, metabolism, and excretion (ADME) and pharmacokinetics of ganaplacide (KAF156) following a single oral dose of 400 mg [14C]ganaplacide in healthy male participants.

In this study we will investigate how quickly and to what extent ganaplacide is absorbed, transported, and eliminated from the body. Ganaplacide will be radioactively labelled with carbon-14 (14C). In this way, ganaplacide can be traced in blood,…

A Phase Ib, Randomized, Double-Blind, Placebo Controlled, Sequential Study of Single Oral Doses of M5717 to Explore the Chemoprophylactic Activity of M5717 in a Controlled Plasmodium falciparum Sporozoite Challenge Model in Healthy Participants

Primary Objectives:- To assess chemoprophylactic activity of single oral doses of M5717 administered after DVI of Plasmodium falciparum sporozoites (PfSPZ) challenge in healthy participants. - To explore the dose-exposure-response relationship of a…