25 results
The aim of this prospective study is 1) to evaluate the diagnostic efficacy of DBE in comparison to MRE as surveillance technique of the small-bowel in PJS patients, 2) to analyze patient burden and quality of life with DBE and MRE, and 3) to…
This study aims to assess the efficacy, safety and effectiveness of LumenR-assisted ESD for the treatment of large rectal adenomas. In addition, the learning curve for this technique in endoscopists with experience in standard ESD is assessed.
To prospectively validate the SERT scoring system for adenoma recurrence rates around the EMR scar after WF-EMR with SCAR technique applied to the defect margin.
The primary objective of this study is to determine the sensitivity of the fluorescent tracer bevacizumab-IRDye800CW using a NIR fluorescence endoscope ans spectroscopy probe in identifying adenomatous polyps during surveillance endoscopy in…
Primary Objective: To identify variants in the humane genome that are associated with BE risk. Secondary Objective(s): We will collect information on BE length, complication of BE (dysplasia, ulcer, stricture or EAC), presence of esophagitis and…
To compare the percentage of incompletely resected polyps during colonoscopy for polyps sized 1-4 mm, 5-9 or 10-20 mm.
The main goals of this study1) To determine the prevalence of BE among first degree relatives of index patients in families that fulfil criteria for familial BE/adenocarcinoma of the GEJ2) Collect tissues of the index patients and all first degree…
To investigate whether bowel relaxation, induced by administration of hyoscine N-butylbromide, improves the detection, removal and colllection of lcolonic polyps during colonoscopy
Primary Objective: To evaluate whether a single intravenous alfentanil bolus (7.5 mcg/kg) has a clinically significant analgesic effect in clinical patients who undergo an elective CT-colonography compared to placebo. We have defined a clinically…
To establish the safety and preliminary efficacy of Check-Cap*s P1 Capsule System in patients eligible for CRC screening
1) Identify chemopreventive properties of mesalazine in patients at high risk of recurrent (nonfamilial) colorectal adenomas by evaluating the effect of treatment on apoptosis and proliferation in histologically normal sigmoid and rectal mucosa…
The SuMO System showed good results for mucosal resection in a porcine model. This study is developed to evaluate the feasibility and safety of the SuMO (submucosal operation) Access and Tissue Resection System in human colon and rectum tissue.
Objective: Two issues will be addressed:i) does pan-colonic chromoendoscopy improve the diagnostic yield of colonic polyps (and in particular flat lesions) as compared to conventional colonoscopy?ii) does pan-colonic chomoendoscopy combined with…
In the present study the effects of the colonic administration of butyrate on portal, hepatic, mesenteric venous and arterial SCFA concentrations will be studied in patients undergoing major upper abdominal surgery. The aim is to clarify the…
To compare the sensitivity and specificity of MR colongraphy with that of CT colonography for the detection of colonic neoplasms, compared to colonoscopy as "gold standard".
This study has been transitioned to CTIS with ID 2023-505455-44-00 check the CTIS register for the current data. Part 1 (phase 1b)Primary:• To observe the safety and tolerability of bemarituzumabSecondary:• To evaluate preliminary antitumor activity…
to determine the number of sufficient quality samples obtained through the use of the Cytosponge, which could potentially serve as a substitute for endoscopic sampling.
To evaluate the consistency and diagnostic accuracy of risk profiles using genetic markers across three different sampling modalities: biopsy, brush sampling, and TOS.
To assess the safety and feasibility of endoscopic papillectomy combined with thermal ablation of the biliary orifice by cystotome and STSC of the lateral resection margins.
The primary objective of this study is to compare the effect on ADR of combining balloon-assisted and CADe assisted colonoscopy, compared to CADe assisted colonoscopy only.Secondary objectives are to compare the effect of adding balloon-assisted to…