18 results
The first goal of the present study is to elucidate the network topology of the MTL on both large-scale and micro-scale levels with the aim of further understanding epilepsy related changes to the network structure. Additionally we will also use the…
In this study one of the goals is to compare 7 tesla MRI with 3 tesla MRI in terms of lesion detection in epilepsy patients and depiction of specific dysplasia-related imaging characteristics. Furthermore, resected tissue will be scanned ex-vivo at…
Compare the combined MRI/MET-PET report to the MRI-only report.
Determination of prognostic value of intraoperative growth hormone levels on postoperative curation for acromegaly in patients undergoing transsphenoidal resection of pituitary adenoma.
Optimalisation of the perfusion protocol for vestibular schwannoma.
Assessment of late effects of radiotherapy in patients with ONSM.
Primary objectiveThe primary objective of this study is to develop and validate a disease-specific PROM, which measures HRQoL in meningioma patients.
Fluorescence guided surgery for intra-operative detection of meningioma using Bevacizumab-IRDye800CW
In the present study, we aim to perform a feasibility study with Bevacizumab-IRDye800CW in patients with meningioma who are scheduled for elective surgical resection. The ability of fluorescence imaging to identify residual meningioma tissue that is…
This will be an explorative study to examine the value of high-resolution ultrasound (HRUS) of the peripheral nerves in NF1 patients. The primary objective of this study is to determine HRUS abnormalities in a large group of NF1 patients, and to…
- To assess maintenance of biochemical control with octreotide capsules compared to placebo in patients with acromegaly, who previously demonstrated biochemical control on SRLs.- To assess maintenance of biochemical control, based on GH, with…
This study has been transitioned to CTIS with ID 2024-512860-75-00 check the CTIS register for the current data. The aim of this feasibility study is to validate pre-treatment [89Zr]-bevacizumab PET/CT as an imaging biomarker for prediction of…
Module 1Primary Objective: To objectify the relation between tinnitus and flocculus activity, quantified by direct response measurements on the flocculus. Tinnitus is quantified by the Tinnitus Functional Index score (TFI), tinnitus pitch and…
Primary objectives:- To determine the PK of selumetinib after administration of the selumetinib granule formulation. - To assess the safety and tolerability of the selumetinib granule formulation.
To compare different methods for visual field testing in young and/or neurologically impaired children, to determine which test is most useful in detecting visual field defects.
To investigate the dose-response relation between cognitive decline and radiotherapy dose for patients with a benign meningioma WHO I.
Phase 1b Dose Escalation Objectives • To determine the safety and tolerability of escalating doses of GB5121• To determine the optimal biological dose (OBD) and/or maximum tolerated dose (MTD), and recommended Phase 2 dose (RP2D) of GB5121 Phase 1b…
Primary objective: Response to trametinib treatment defined as a tumor volume decreases from baseline of >=20%, monitored by using volumetric MRI analysis. Secondary objectives are: patient reported outcomes of pain and disability and quality…
In this study, we will investigate what changes in brain activity when we test language function and if this can be detected on a High-Density electroencephalogram (HD-EEG). As part of this study, we will also temporarily disrupt brain activity…