131 results
Primary objective of this study is to assess the safety and tolerability, feasibility and biological activity (immunogenicity) of the actively personalized vaccination (APVAC) concept in newly diagnosed glioblastoma (GB) patients.Secondary study…
A pilot study of the feasibility of 11C-MET as postoperative baseline scan in the follow-up of high-grade gliomas for the detection of tumor recurrence.
Phase A:Primary objective: Determining the feasibility of gemcitabine as a radiosensitizer in DIPG Secondary objective: Evaluation of efficacy in terms of clinical and radiological response rate and progression free survivalTertiary objectives:…
Primary Objective: The overall aim of this study is to develop a reliable and valid IADL questionnaire for use in brain tumor patients. Parallel versions of this questionnaire will be developed; a patient-based version and a proxy-based version.…
The primary study objectives are: (1) to determine the impact of glioma and its treatment on the neurocognitive functioning, health-related quality of life, and mental functioning of LGG patients; and (2) to determine the impact of the disease and…
Primary objective of this study is to assess the correlation between tip of the nose motion and head motion. Secondary objective is to assess the immobilization capacity and comfort of different masks in the context of SRS with the ICON system.
Primary objective: to non-invasively characterize the IDH1-mutational status of gliomas in patients by measuring the ratio of GPC/PE with 31P MRSI and 2HG content by 1H MRSI in the same examination. This is expected to make the identification of the…
Primary objective* to determine GTV in patients with an untreated GBM with 7T MRI without contrast-enhancement.Secondary objective* to compare the GTV as created based on 7T MRI to the GTV based on 3T MRI.* to determine the clinical target volume (…
to establish primary patient derived organoid cultures from GM to study mechanisms that contribute to aggressive tumor growth and treatment resistance in primary and recurrent GM.
Determining VEGF expression in pHGG and DIPG using 89Zr-Bevacizumab
The aim of this pilot study is to obtain datasets that can be used to optimize high-resolution CTP and compare image quality to current standard techniques such as standard CTP and MR perfusion imaging (T2*-weighted DSC-MRI) in a group of patients…
The primary objective is to investigate the safety and efficacy of LDE225 with respect to overall response rate according to independent central review (ICR).The key secondary objective is to assess LDE225 with respect to progression-free survival (…
Primary objective:To assess the feasibility of KD in patients with glioblastoma multiforme during standard treatment.Secundary objectives:- To determine number of patients not being able to start protocol treatment (i.e. not able to reach ketosis,…
The aim of this study is to understand what it means to be anxious for adults with a malignant glioma. This study focuses on the lived experience and the underlying processes of the meaning of anxiety.Main question: "What does it mean for…
Primary objectives: Part I: Feasibility of 89Zr-GC1008 PET imaging in patients with suspicion of a malignant glioma to assess if GC1008 penetrates into the brain tumor and to quantify its uptake. Part II: 89Zr-GC1008 PET imaging in patients with…
1. Protocol A: Laser Speckle Imaging (LSI) of blood flow changes coupled to neuronal activity in the human cerebral cortex: To investigate and optimize the use of LSI to visualize blood flow changes coupled to neuronal activity. The aim is to…
this study aims to evaluate the clinical value of ASL in the clinical MRI protocol of children with a brain tumor. To serve the sample size calculation, its primary objective is to assess whether there is a correlation between perfusion of (parts of…
GBM is difficult to treat, due to the fact that tumor cells can move until several centimeters in the brain around the visible tumor location. these infiltrated cellscan not be removed by surgery and are resistant to chemotherapy and radiation. This…
(1) Determination of the effect of dexamethasone on the biodistribution and kinetics of [11C]TMZ in GBM patients. (2) The effect of DXM on CBF. If there is an effect of DXM on CBF: (3) The effect of blood flow in the brain on [11C]TMZ uptake.
The objectives of this study are to assess the penetration of RO532441 into recurrent GBM by 89Zr-RO5323441 PET imaging and to quantify its uptake, to visualize and quantify 89Zr-RO5323441 organ distribution, and to measure effect of bevacizumab…