193 results
To investigate the impact of the multispecies probiotic product Ecologic*Barrier on neurocognitive measures of emotion and executive functioning.
The primary objective of this study is to predict the antidepressant treatment outcome of ECT in patients with severe depressive symptomatology using neuroimaging. ECT itself is conducted as usual according to national guidelines (Nederlandse…
The present study will evaluate potential etiological models for sleep disturbances, depressive symptoms and cognitive impairment using an innovative idiographic design using time-series analysis that accounts for both intra-individual variability (…
(1) To investigate the efficacy of LT in patients with T2DM and comorbid depression, and (2) whether LT leads to improved insulin sensitivity, and (3) whether effects on mood and metabolic control are mediated by restoration of the circadian…
The primary objective is to assess feasibility of a food supplement (multispecies probiotic) placebo-controlled, randomised controlled, double blind intervention in pregnant women in their late second/third trimester of pregnancy, to reduce symptoms…
To investigate whether bright light therapy is an effective treatment for depression during pregnancy compared with low-intensity placebo light therapy (proof-of-principle) and to investigate the late effects of bright light therapy versus placebo…
(1) To investigate the effect of rTMS in a treatment set-up of 4 weeks including sham-rTMSas a control in 2 x 50 patients who have had at least two prior antidepressant therapies and psychotherapy according to the Dutch guideline of depression.(2)…
The main objective of the study is to investigate whether a 9 week MFT for adolescents with ASD and clinically elevated internalizing symptoms, reduces adolescent's internalizing symptoms. Secondary objective is to investigate the process of…
To investigate the effect of JNJ-42847922 given as monotherapy as compared to placebo on symptoms of depression in male and female MDD patients
Identification of genetic variations that control monoamine and amino acid metabolism in humans, by translating recent genetic findings in non-human primates to a human cohort.
The current project is aimed at examining the reasons for not participating in preventive services systematically and to make an overview of possible solutions. A second goal is to make an overview of reasons for (not) participating in interventions…
We aim to assess the effect of high-dose vitamin D supplementation on non-specific musculoskeletal complaints in non-Western vitamin D-deficient immigrants and to determine whether improvement of mood is associated with this effect.
Primary ObjectiveThe primary objective of this study is to assess whether the antidepressant response to IV ketamine can be maintained by minocycline compared to placebo.Secondary ObjectivesThe secondary objectives of this study are:* To investigate…
To evaluate the effect of intranasal esketamine 84 mg on cognition, and duration of cognitive effects (if present), as assessed using a computerized test battery (Cogstate®).
The objective of this study is to establish the (cost) effectiveness of transmural collaborative care including a Consultation Letter for the GP and duloxetine (TCCCL) versus Duloxetine in patients with depression that present themselves with (sub)…
The objective of this study is to gain better inside in decision-making in the treatment of mood and anxiety disorders and treatment preferences of both patients and clinicians. We will explore factors that determine decisions and look for possible…
This study aims to investigate how serotonin influences social functioning in healthy adults with a first-degree family member diagnosed with MDD. The primary goal is to investigate the effect of an experimental increase in brain serotonin on…
The primary aim of this study is to measure the effect of light therapy on mood in depressed Parkinson patients. In addition, we measure the effect of light therapy on sleep, motor functions, circadian rhythms and quality of life.
Primary ObjectiveTo evaluate the effect of JNJ-42847922 on sleep latency (latency to persistent sleep [LPS]) in MDD subjects, stably treated with an SSRI/SNRI, who suffer from insomnia.Secondary Objectives* To investigate the safety, tolerability,…
To examine the protective effects of a single session of high frequency rTMS over the left dorsolateral prefrontal cortex on negative mood and motivated attention.