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Ghrelin concentrations in gestational diabetes.

To compare acylated and unacylated ghrelin concentrations in pregnant women with GD and without GD.

Assessing and predicting functional and quality of life-related outcomes of islet and pancreatic transplantation in patients with type 1 diabetes mellitus

There are two objectives for this study: first, to find specific serum beta cell damage markers that can serve as a clinical predictive tool for beta cell allograft loss. Second, to compare quality of life and diabetes-related outcomes in patients…

Laser therapy for onychomycosis in patients with diabetes at risk for diabetic foot complications
A randomized, double blind controlled trial.

To determine the efficacy and safety of laser therapy in diabetes patients with risk factors for developing diabetic foot complications.

Depressive symptoms, sleep quality and cognitive functioning in outpatients with type 2 diabetes

The aim of this study is to investigate the prevalence of impaired cognitive functioning in outpatients with DMT2. Second, we will investigate the relationship between impaired cognitive functions and sociodemographic factors, clinical features and…

Activation of the innate immune system and vascular inflammation in patients with type 1 diabetes mellitus

Primary Objective: 1. To determine whether there is a difference in arterial wall inflammation between well-controlled and poorly-controlled type 1 diabetes patients2. To determine whether patients with type 1 diabetes have a higher level of…

Magnetic Resonance Assessment of Victoza Efficacy in the Regression of Cardiovascular Dysfunction In Type 2 Diabetes Mellitus

Study 1:1) To test the hypothesis that Liraglutide improves cardiovascular function in DM2 patients and whether the improvement is associated with redistribution of ectopic fat stores. 2) To test the hypothesis that Liraglutide activates BAT in DM2…

A multicenter, international, randomized, parallel group, double-blind, placebo-controlled, cardiovascular safety and renal microvascular outcome study with linagliptin, 5 mg once daily in patients with type 2 diabetes mellitus at high vascular risk. CARMELINA

The primary objective is to demonstrate non-inferiority (by means of comparing the upper limit of a two-sided 95% confidence interval with the non-inferiority margin of 1.3) of treatment with linagliptin in comparison to placebo (as add-on therapy…

A Randomized, Multicountry, Multicenter, Double-Blind, Parallel, Placebo-Controlled Study of
the Effects of Atrasentan on Renal Outcomes in Subjects with Type 2 Diabetes and Nephropathy

The study objective is to evaluate the effect of atrasentan compared with placebo on time to doubling of serum creatinine or the onset of end stage renal disease (ESRD) in subjects with type 2 diabetes and nephropathy who are treated with the…

String of Pearls - Diabetes Cohort: Generation of a Dutch academic Bio-Databank for the study of the etiology of type 2 diabetes mellitus and related diseases and complications

The goal of the *String-of-Pearls national academic biobank - the diabetes cohort* is to create a nation diabetes bio-databank, with DNA, urine and blood samples of 12.000 diabetespatients in combination with clinical data from the diabetes care in…

Cold Atmospheric Pressure Plasma as a Novel Treatment Modality in Diabetic Foot Ulcers: a Pilot Study

Primary Objective: 1. To investigate the safety of cold plasma plaster treatment of diabetic foot ulcers. Secondary Objective(s): 1. To investigate the effect of cold plasma plaster treatment of diabetic foot ulcers on bacterial load.2. To…

A Phase 3 Randomized, Placebo-Controlled, Blinded Study to Investigate the Safety and Efficacy of a Topical Gentamicin-Collagen Sponge in Combination with Systemic Antibiotic Therapy in Diabetic Patients with an Infected Foot Ulcer

Primary Objective:To determine the effect of the Topical Gentamicin-Collagen Sponge (gentamicin-sponge) in combination with systemic antibiotic therapy compared to placebo-sponge and no-sponge, both in combination with systemic antibiotic therapy on…

Offloading the diabetic foot: a direct comparison of the total contact cast, bivalved total contact cast and cast shoe

To assess the efficacy of a TCC, a BTCC and a cast shoe with similar plantar soles on offloading the previous ulcer location in people with DM and peripheral neuropathy.

Orthopaedic footwear concepts for the diabetic foot: effect on pressure relief and patient satisfaction

To assess the efficacy of different orthopaedic footwear concepts on the plantar pressure and patients satisfaction in diabetic patients at risk for foot ulceration

A Double-Blind, Placebo-Controlled Phase 2 Study to Evaluate the Effect of CCX140-B on Albuminuria in Subjects with Type 2 Diabetes Mellitus

The primary efficacy objective of this study is to evaluate the effect of CCX140-B treatment on urinary albumin excretion in subjects with type 2 diabetes mellitus (T2DM) with albuminuria.The primary safety objective of this study is to evaluate the…

A Phase III, Double-Blind, Placebo Controlled, Parallel Group, International, Multicenter Study of 12 Weeks Treatment with Trafermin 0.01% Spray in Patients with Diabetic Foot Ulcer of Neuropathic Origin.

Trafermin spray is a new treatment that is being studied in wound healing and particularly for the treatment of diabetic foot ulcers. When trafermin is sprayed onto a wound, it stimulates the skin and blood vessels to grow again and so speeds up the…

Generation of subject-specific, dynamic, multi-segment ankle and foot models to improve the design of foot and ankle foot orthoses

To generate the information required to produce accurate and dynamic computational models of the human foot and ankle for the purposes of orthotic development.

the effect of felted foam on peak pressure relief and preservation in the feet of healthy individuals

The current research project will investigate the pressure relieving and preservation effects of felted foam. The aim of this study is to find the type of felted foam that is most effective in reducing plantar peak pressures. Furthermore, this study…

Butyrate Use in TYpe 1 diabetes: effects on Regulation of bActerial translocation, innate immunity, T-cell function and Endotoxemia

To investigate whether ingestion of 4 grams of butyrate daily during 4 weeks can positively affect the immune system function, residual betacell function and low grade inflammation in patients with type 1 diabetes mellitus.

Understanding adherence of adolescents with type 1 diabetes by measuring the daily tasks, bolus frequency and blood glucose levels.

The purpose of this observational study is to investigate the adherence during 2 months in adolescents with type 1 diabetes on subcutaneous insulin pump therapy. The main outcome measure will be the amount of insulin bolusses and glucose…

A randomized, double-blind, double-dummy, multi-center study to assess safety and efficacy of BAY 94-8862 in subjects with emergency presentation at the hospital because of worsening chronic heart failure with left ventricular systolic dysfunction and either type 2 diabetes mellitus with or without chronic kidney disease or moderate chronic kidney disease alone versus eplerenone

Primary objective of the study is• To investigate efficacy and safety of different oraldoses of BAY94-8862 given once daily over 90 daysThe secondary objectives are:•To assess the effects of these doses on a compositeendpoint of death from any cause…