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Prevalence Estimate Chlamydia and Gonorrhoea Netherlands

To obtain an estimate of the prevalence of chlamydia and gonorrhoea among men and women aged 18 to 34 years.

Investigating the relationship between mobile phone usage and emotions. A pilot study using the experienced sampling method

The objective of this study is to investigate whether there is a relation between smartphone usage and psychological parameters in young adults. Taking into accordance the type of research (explorative, observational) and the present state of…

The influence of high frequency 10Hz repetitive transcranial magnetic stimulation (rTMS) on experimental pain measured through quantitative sensory testing in healthy subjects.

to investigate the analgesic effect of high frequency 10 Hz rTMS on experimental pain measured through quantitative sensory testing (QST) in healthy subjects.

A follow-up study of the Discontinuation of ANtihypertensive treatment in the Elderly (DANTE) study Leiden

To assess the association between baseline blood pressure and change in neurocognitive functioning after four years, and to assess whether baseline MRI phenotypes are predictive for changes in neurocognitive functioning after four years in the DANTE…

A Two-Part, Randomized, Placebo and Active-Controlled, Double-Blind, Thorough QT Study Evaluating the Effects of Intravenous Exenatide on Cardiac Repolarization in Healthy Male and Female Volunteers.

Part A Pilot:The purpose of Part A is to investigate how quickly and to what extent exenatide is absorbed and eliminated from the body and whether the plasma levels of exenatide will reach the levels seen in patients with renal impairment. It will…

Longitudinal Aging Study Amsterdam, a solid infrastructure for the social science of ageing in the oldest-old

The aim of the study is to expand an existing infrastructure for scientific research, i.e. a longitudinal observational study, for investigating physical, emotional, cognitive and social trajectories of functioning, their determinants and their…

Sample collection for assessment of variability of metabolite and protein biomarkers in healthy male volunteers

Collection of blood and urine samples for estimation of the metabolomic and proteomic intra- and inter-subject variation for an extensive set of biomarkers in healthy male volunteers.

Pilot study 'Mindfulness for people with burns and parents of children with burns: feasibility and potential effect of a first mindfulness training'

Aim of the study is exploring the feasibility and potential effect of a Mindfulness training for people with burns and parents of children with burns.

A novel method to assess VO2max in a respiration chamber

The current study aims to develop a novel approach to assess VO2max without any breathing restriction at the mouth by measuring maximal oxygen uptake in a respiration chamber.

The impact of EcologicBarrier on neurocognitive measures of emotion & executive functioning

To investigate the impact of the multispecies probiotic product Ecologic*Barrier on neurocognitive measures of emotion and executive functioning.

Effect of Delmopinol on treatment of Peri - implant mucositis : a randomised controlled clinical trial

The primary objective of this study is to evaluate the effect (reduction of bleeding on probing) after mechanical debridement alone or treatment with delmopinol or chlorhexidine mouth rinse as an adjunct to mechanical debridement around implants…

The effects of internal and external attentional focus instructions on motor learning after stroke

The primary objective of this study is to assess whether motor learning using external attentional focus instructions results in superior single-task motor performance, movement automaticity, and dual-task performance in inpatient stroke patients…

A Randomized Clinical Trial of Cutaneous Xylocaine Spray to Reduce Intravenous Cannulation Pain in Adults.

Objective: Adequate analgesia during intravenous cannulation.Hypothesis: Xylocaine spray for the placement of an infusion decreases the pain score with two or more points in comparison to placebo spray.Studie questions:Primary: Has xylocaine spray…

A double-blind, placebo controlled, randomised, parallel group study with an open-label cross-over part, investigating safety, tolerability, pharmacokinetics, and pharmacodynamics after single ascending oral doses and a single intravenous dose of the vasopressin V2-receptor agonist FE 201836

The purpose of the study is to investigate to what extent FE 201836 is tolerated. It will also be investigated how quickly and to what extent FE 201836 is absorbed and eliminated from the body (this is called pharmacokinetics). Also the effect on…

Pain in Dementia- Prevalence and Diagnostics

Objectives: 1. To assess the prevalence of pain in elderly with dementia and to study the relationship between the various subtypes of dementia and the presence of specific types of pain(e.g. nociceptive pain, neuropathic pain, and orofacial pain).…

The amount of light to achieve optimal alertness as a function of time of day

This study aims to measure the action spectra of alertness at different time points of the day. The question to be answered is how time-of-day modulates the amount of light that is needed for optimal alertness. This project will result in a dose-…

Employing dynamic kinetic responses to demonstrate the effectiveness of dietary intervention: A challenge-based study using a low-glycaemic load diet

Primary objective: To assess the impact of a low glycaemic load (GL) diet as compared to a *Western* diet on metabolic flexibility (the change in RQ) upon a hyperinsulinemic euglycemic clamp. Secondary objectives: 1) To assess the impact of low GL…

Single center ethical protocol for donation of skin tissue and blood samples by patients suffering from psoriasis vulgaris for animal studies concerning development of new treatments for psoriasis vulgaris.

Collection of skin tissue and blood samples from patients with mild to moderate psoriasis for efficacy testing of a reference compound, for subsequent testing of a new therapeutic in a humanized mouse model.

Cortical mechanisms of vestibular influence on hand choice.

The main objective is to investigate the preparatory process in left primary motor cortex in relation to hand choice during whole-body motion.

A randomized, double-blind, placebo-controlled, parallel, single center study to investigate the pharmacokinetics, safety, and tolerability of Estetrol (E4) in combination with Drospirenone (DSRP) after single and multiple dosing in healthy women.

The purpose of the study is to investigate how quickly and to what extent single and multiple doses of Estelle® are absorbed by and eliminated from the body (this is called pharmacokinetics). It will also be investigated how safe Estelle® is and how…