12 results
First objective: To assess improvement in live birth rate after levothyroxine supplementation. Secondary objective: 1) to test the hypothesis that levothyroxine lowers the risk for miscarriage and preterm birth 2) to test the hypothesis that…
Th**is study will compare sequential mifepristone and misoprostol (*M&M*) treatment versus misoprostol treatment alone, which is currently the standard medical treatment in the Netherlands.
The objective of this study is to collect blood samples of women who participated in the ALIFE trial, to test for several DNA-variations as well as anti β2 glycoprotein antibodies, but also to perform overall coagulation assays, such as clot lysis…
To evaluate and obtain insight into psychological, social and moral factors in thoughts and attitudes of pregnant women and their partners carrying a fetus with an isolated CL ± P in order to improve counseling.
To increase our understanding of the developmental significance of chromosomal mosaicism in preimplantation embryos by investigating their implantation potential and the fate of abnormal cells after an in vitro implantation procedure.
In this study we aim to compare the effect of two different ovarian stimulation protocols on embryo quality in a group of women of 39 years or younger, in a prospectively randomized controlled trial. PGS will be performed to assess chromosomal…
To test the hypothesis that in women with unexplained recurrent miscarriages, progesterone started as soon as possible after a positive pregnancy test ) and continued to 12 weeks of gestation, compared to placebo, increases live births beyond 24…
We intend to employ an ex vivo model of human implantation to study the factors involved in successful implantation. By linking parameters of successful implantation with embryo quality markers, we aim to improve embryo selection and IVF outcomes.…
Primary Objectives: - To evaluate the safety in mother and neonate/infant of nipocalimab administered to pregnant women at high risk for EOS-HDFN. - To evaluate the efficacy of nipocalimab as measured by proportion of patients with live birth at or…
Primary Objective: - to establish if a gut microbiome perturbation affects APS disease phenotype.Secondary Objective(s): - to identify biomarkers that are responsive gut microbiome perturbation.- to establish if gut microbiome perturbation affects…
This study is conducted to discover if bacterial vaginosis is related to the pregnancy rate in couples undergoing assisted reproduction.
This study will compare sequential mifepristone and misoprostol treatment versus misoprostol treatment alone, which is currently the standard medical treatment in the Netherlands.