47 results
Determine the existence of a relation between GER and apnea and their underlying mechanisms, in infants *37 weeks * 12 months.
Is to identify the incidence and prevalende of PH in premature born infants. In addition we will identify possible risk factors for the development of PH and we want to determine the prognosis and survival of these patients. PrimaryTo determine the…
To assess the accuracy and cost-effectiveness of PO screening for CCHD in the Dutch perinatal care system.
To describe the synchronicity of nIPPV respiratory support with spontaneous diaphragm activity and the effect of asynchrony of mechanical inflations and spontaneous breaths on lung volume, mechanical parameters and diaphragm activity in preterm…
To identify alternative dEMG electrode positions in preterm infants for cardio-respiratory monitoring.
Recently, population PK/PD modeling and simulation studies have enabled the development of evidence-based individualized dosing schemes for children with a limited number of subjects, thus improving drug safety and efficacy. The application of PK/PD…
In this multicenter trial we compare resuscitation of preterm neonates with either 5 cm H2O PEEP or 8 cmH2O PEEP. We think resuscitation with 8 cmH2O PEEP results in a better outcome compared to resuscitation with 5 cmH2O PEEP.
Primary objective: -to determine if there is a significant difference in the incidence of oxygen dependency at day 28 and/or death within the first 28 days of life between newborns with congenital diaphragmatic hernia treated with high frequency…
The development of a disease specific questionnaire to measure the quality of life in children with BPD at age 4-8, that can be answered by the parents.
The primary objective is to determine if echocardiography in combination with plasma biomarkers can be used as a potential predictor for pulmonary hypertension. The secondary objectives are assessment of a potential correlation between…
1. Feasibility and reproducibility of transcutaneous (tc) dEMG on premature neonates. - Are the signal quality (heart rate and respiratory rate), bradycardias and apneas similar to the current impedance monitoring2. Can we differentiate between…
The objective of this study is to obtain physiological data on lung aeration during pulmonary transition in newborn infants.
Objective: to obtain lung function parameters in infants born preterm at the age of 6 months and to evaluate risk factors for impaired lung function
Primary objective- Survival without BPD at 36 weeks gestational age (GA)Secondary objectives- Neurodevelopment at a corrected age of 18-22 months- Adverse treatment effects- Mortality at 36 weeks gestational age- BPD incidence at 36 weeks…
The main objective of this study is to determine if Low-Flow is non inferior in reducing apneic spells compared to caffeine. Secondary objectives are investigating if these treatments have an effect on the need of supplemental ventilation and on the…
Primary Objectives: The primary objectives of this study are to evaluate the efficacy and safety of IV sildenafil when added to iNO for the treatment of neonates with PPHN or hypoxic respiratory failure and at risk for PPHN. Secondary Objectives: *…
The objective of this study is to investigate ABG, CBG and VBG (or parts of the blood gas analysis) in infants.
Monitoring the haemodynamic status during lung recruitment.
The primary objective is to obtain insight in regional differences in lung volume and ventilation distribution during apnea of prematurity and its farmacological treatment. Furthermore, the effect on these parameters due to position changes and non-…
To determine the feasibility of umbilical PO for HR measurements after cord clamping in infants needing stabilization at birth and to compare this with standard PO on the right hand.