11 results
Primary Safety Objective * Proportion of patients who complete 24 weeks of combination treatment on pirfenidone at a dose of 1602*2403 mg/d and nintedanib at a dose of 200*300 mg/d Secondary Safety Objective * Proportion of patients who discontinue…
Primary Objective:* To determine if TTFields in combination with pemetrexed/platinum improves overall survival (OS) compared to historical control in patients with unresectable mesothelioma.Secondary Objectives:* To evaluate the overall response…
This study will evaluate the efficacy, safety, and tolerability of sildenafil or placebo added to pirfenidone treatment (study treatments) in patients with advanced idiopathic pulmonary fibrosis (IPF) and intermediate or high probability of Group 3…
Primary objectiveTo detect the difference in mean arterial blood pressure between conventional APRV settings and APRV settings based on EIT measurements, in patients with ARDS.Secondary objectivesImproved dorsal ventilation distribution on EIT…
Primary Efficacy Objectives• To compare the overall survival (OS) in subjects with malignant pleural mesothelioma receiving VS-6063 or placebo.• To compare the progression free survival (PFS) in subjects with malignant pleural mesothelioma receiving…
The primary objective is to determine the efficacy (as measured by pulmonaryfunction) and safety of CNTO 888 in subjects with IPF. The major secondary objectives are to assess theeffect of CNTO 888 on measures of disease progression, to assess the…
Primary objective- To define the optimal pressure support level for homogeneous lung ventilation during PSV, based on EIT measurements, in patients with and without lung disorders.Secondary objectives- Improved oxygenation compared to baseline-…
We expect to finalize the current phase I study by the May 2008 demonstrating that injection of tumor lysate-pulsed autologous DCs injected in patients with MM after chemotherapy is safe and well tolerated with induction of immune responses. New…
To evaluate the efficacy of manual aspiration in comparison to conventional chest tube drainage in pneumothorax therapy:1.whether the lung will expand by means of clinical and radiological findings.2.whether manual aspiration will shorten hospital…
MAIN QUESTIONIs there any difference in the lungfunction of those people, who have undergone surgical intervention since 1985 in relation to a childhood empyema, compared to the refence population?Which determinants caused a degraded pulmonary…
To describe criteria on CLE-imaging of different entities (thoracic wall/ pleura/ fibrosis/ mediastinum) compared to histology.