15 results
To establish if and how the endocannabinoid system is involved in ADHD and related symptoms. This will be investigated by assessing the acute effects of a cannabinoid agonist (THC) on brain function related to ADHD and ADHD symptoms.
• Identify regional specificity of dopaminergic drug effects, i.e. the distinct behavioural roles of dopamine in the striatum and dopamine in the prefrontal cortex.• Identify receptor specificity of dopaminergic drug effects, i.e. the distinct…
The proposed research project will examine the potential benefits of a *gamified* working memory training for adolescents in addiction care. The primary objective is to test whether a gamified working memory training will lead to improved working…
Primary:* To investigate the safety and tolerability of the co-administration of GSK598809 at175 mg and ethanol in healthy volunteers.* To examine the potential pharmacokinetic interactions between GSK598809administered at 175mg and ethanol in…
The main objective of this study is to determine whether and how the endocannabinoid system is involved in psychiatric disorders. We test this by assessing the acute effects of a cannabinoid agonist (THC) on brain systems that are known to be…
Primary objective- To assess the effects of Org 25935 on heavy drinking in subjects with alcohol dependence.Secondary objectives- assess the effects of Org 25935 on the amount of drinking- To assess the effects of Org 25935 on the first relapse to…
The present study focusses especially on the value of cognitive skill training within a program of work integration by means of IPS. Research shows that these interventions indeed lead to enhanced cognitive skills (Wykes et al. 2011). According to…
The primary goal is of this pilot study is to investigate the effects of Computerised Interactive Remediation of Cognition - a Training for Schizophrenia (CIRCuiTS), on the cognitive functioning of the described group of service users. It is…
Primary- To investigate the safety and tolerability of JNJ-55363932 after single oral dose administration(ascending dose levels) in healthy participants- To characterize the PK of JNJ-55363932 in plasma, cerebrospinal fluid (CSF) and urine…
The primary objective of this study is to assess tolerance and efficacy of 12 weeks BP1.3656 (30 µg or 60 µg OD versus placebo) to reduce alcohol consumption in alcohol dependent patients.
The main objective of this study is to investigate whether rTMS treatment will improve clinical outcomes in body dysmorphic disorder, by reducing BDD YBOCS outcomes. Furthermore to improve localization and rTMS treatment in the dorsolateral…
Our primary objective is to investigate whether oxytocin administration can affect empathy and emotion recognition in healthy and antisocial adolescents. We expect that oxytocin will enhance empathy and emotion recognition in both healthy and…
To evaluate whether cue-induced nicotine craving and cognitive control in smoking individuals can be modulated with cTBS at left or right insula using deep TMS.
A possible treatment approach is cognitive remediation training (CR), a training developed to target cognitive deficits with the ultimate aim to improve daily functioning. Participants engage in cognitive exercises, learn more about their own…
The aim of the study is to investigate whether inhibition of the left or right insula has differential effects with regard to clinical outcomes (i.e. smoking cessation/reduction), cognitive processes (i.e. cognitive control, craving and goal-…