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Assessment of Safety, Tolerability, and Efficacy of Donanemab in Early Symptomatic Alzheimer*s Disease

This study has been transitioned to CTIS with ID 2023-507303-55-00 check the CTIS register for the current data. To assess the effect of donanemab versus placebo on clinical progression in participants with early symptomatic AD with demonstrated…

Pamidronate for pain in adult chronic nonbacterial osteitis (PAM-CNO): a randomized, double-blind, placebo-controlled trial

This study has been transitioned to CTIS with ID 2023-510309-16-00 check the CTIS register for the current data. The primary objective to demonstrate that in CNOpatients with pain 3-monthly treatment with pamidronate will result in significant…

'BATMAN' antibiotics against amyloid angiopathy: a placebo-controlled, randomized, double-blind study of minocycline for sporadic and hereditary cerebral amyloid angiopathy.

To prove in a randomized clinical trial in a translational setting that minocycline treatment (duration 3 months) can decrease markers of neuroinflammation and the gelatinase pathway in the cerebrospinal fluid (CSF) of patients with HCHWA-D (n=30)…

A Phase 3, randomized, double-blind, efficacy and safety study comparing SAR442168 to placebo in participants with nonrelapsing secondary progressive multiple sclerosis

Primary: To determine the efficacy of SAR442168 compared to placebo in delaying disability progression in nrSPMSSecondary: 1. To evaluate safety, tolerability, and efficacy of SAR442168 compared to placebo on clinical endpoints, MRI lesions,…

A Phase 2 Randomized, Double-blind, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of AL002 in Participants with Early Alzheimer*s Disease

To evaluate the efficacy of AL002 in participants with Early AD in delaying disease progression compared to standard of care