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Human intestinal ischemia and reperfusion

This study aims at (further) revealing the pathophysiology of intestinal IR in man, with a specific interest for the role of proteases and protease-activated receptor-2 (PAR-2), cellular and inflammatory changes, barrier function and intestinal…

The effect of botulinum toxin type A injections in the m. rectus femoris in stroke patients presenting with stiff knee gait

To determine the effect of botulinum toxin type A injections in stroke patients with stiff knee gait.

Postprandial insulin release and the impact on muscle perfusion

We hypothesize, that during an oral glucose tolerance test, the OPS arterial flow measured sublingual will be comparable within the same subject, but different between young, elderly and type 2 diabetic patients. Objective is to quantify differences…

Perioperative esmolol infusion for haemodynamic stability during major vascular surgery.

Primary Objective: comparing hemodynamic stability provided by titration of esmolol in addition to standard perioperative care including low-dose metoprolol to placebo and standard care.Secondary Objective(s): -comparing the incidence of…

Effects of postprandial hyperglycemia on aortic elasticity in impaired glucose tolerance and diabetes mellitus type 2

We aim to study the short-term effects of postprandial hyperglycemia in patients with impaired fasting glucose and in patients with T2DM on aortic stiffness as measured by PWV. Secondly, we study the effects of postprandial hyperglycemia on the…

Systemic effects of mild renal insufficiency: the relation between forearm blood flow and ADMA.

The results of this study will give better insights in the role of ADMA in the development of systemic endothelial dysfunction.

The influence of ACTH on blood coagulation

The primary objective of this clinical controlled trial is to define the overall effect of adenocorticotropic hormone on coagulation parameters in patients with primary adrenal insufficiency (as diagnosed by their physician by previous short ACTH…

TIN FOIL FOR PREVENTION OF FANTOM LIMB PAIN AFTER A LOWER LEG AMPUTATION, CAUSED BY COMPLICATED VASCULAR DISEASE: a randomised cross-over study

application of tin foil on an amputated leg deminishes fantoom pain

Bevacizumab and endothelium dependent vasodilation

To determine the effect of bevacizumab on the vasodilator response of acetylcholine in humans by using plethysmography.To determine the effect of bevacizumab on the vasodilator respons of nitroprusside in humans by using plethysmography

Does ticagrelor modulate the inflammatory respons to human endotoxemia?

To study whether ticagrelor, added to acetylsalicylic acid, modulates the inflammatory response to the administration of lipopolysaccharide (LPS) in humans in vivo.

A Two-Part, Open-Label, Randomized, Placebo-Controlled, Crossover Study to Assess the Reversal of the Anticoagulant Effects of milvexian by 4-Factor Prothrombin Complex Concentrate (4F-PCC) (Part 1) and Recombinant Human Factor VIIa (rFVIIa) (Part 2) in Healthy Subjects

The study will be performed in 2 parts, Part 1 and Part 2. Part 2 has been clinically completed. The remainder of this document concerns Part 1 only. The purpose of Part 1 of this study is to determine the reversal of the blood thinning effects of…

Specifying the anti-inflammatory effects of ziltivekimab with diverse imaging modalities and in-depth cellular phenotyping

This study has been transitioned to CTIS with ID 2024-515893-29-01 check the CTIS register for the current data. To study whether ziltivekimab therapy reduces arterial wall inflammation as assessed by imaging, and reduces the systemic inflammatory…