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Reduction of otoacoustic emission with transcranial magnetic stimulation (TMS) of the auditory cortex

The main objective is to demonstrate the activation of the efferent inhibitory cortico-olivocochlear pathway with otoacoustic emission of the ear contralateral to the side of stimulation with TMS. We expect the amplitude to decrease after TMS of the…

First-in-human, placebo-controlled, ascending dose study to assess the safety, tolerability and pharmacokinetics of a single intratympanic injection of AC102 in healthy volunteers

The primary objective of this study is: * To assess the safety and tolerability of single ascending volumes of placebo as well as volumes and doses of AC102-suspension by intratympanic injection in healthy male and female subjects.The secondary…