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Quadrivalent HPV vaccination after effective treatment of Anal Intraepithelial Neoplasia in HIV+ men (VACCAIN-P)

The primary objective of the current study is to assess the efficacy of qHPV vaccination in preventing recurrence of high-grade AIN in HIV+ MSM with CD4 counts >350 x 10E6/l who were successfully treated for high-grade intra-anal AIN in the…

Hypertonic saline in primary ciliary dyskinesia: a pilot study

We hypothesize that hypertonic saline nebulizations improve respiratory symptoms and quality of life in PCD patients.

Is antibiotic treatment associated with reduced risk of a subsequent exacerbation and mortality in chronic obstructive lung disease? A randomized clinical trial.

Study objective: To evaluate the long-term (cost-)effectiveness of antibiotic treatment added to corticosteroids in the treatment of exacerbations of COPD.

The Qure study: Q-fever fatigue syndrome - response to treatment

To assess the efficacy of two treatment strategies for fatigue and disabilities in QFS: long term treatment with doxycycline or cognitive behavioral therapy (CBT).

Maraviroc Immune Recovery Study (MIRS):
A multicentre, randomized, placebo-controlled, exploratory mechanistic study into the role of Maraviroc on immune recovery

The primary objective is to confirm the hypothesis that Maraviroc stimulates immune recovery; the ssecondary objective is to explore, by virologic and immunologic investigations, the underlying mechanisms of this hypothesis.

Exploring prophylactic co-trimoxazole regimens at the removal of temporary catheters to prevent urinary tract infections: a randomised placebo controlled pilot study

To determine a suitable co-trimoxazole regimen for testing in a future larger clinical trial to determine the efficacy of antibiotic prophylaxis in patients with a temporary urinary tract catheter.

Relevance of Biomarkers and Clinical Predictors of Outcome in Unselected Population with Febrile Urinary Tract Infection at Primary Care and Emergency Department in a Prospective, Randomized Cohort Trial Comparing Short (7 days) Antibiotic Treatment with Conventional Treatment (14 days)

To assess clinical parameters and biomarkers in blood and urine in predicting bacteremia, need for hospital admission, clinical and bacteriologic cure and mortality in patients with fUTI.To determine whether a 7-day duration of antibiotic treatment…

Effect of Dientamoeba fragilis eradication on symptoms in children with abdominal pain

Effectiveness of treatment with clioquinol on parasitologic eradication is being studied as well as the clinical effectiveness of eradication in children with dientamoeba fragilis infection.

A Phase IV Clinical Trial to Evaluate the Safety and Tolerability of ZOSTAVAX in Subjects >=60 Years of Age

The objective of the study is to evaluate the general safety of ZOSTAVAX* in subjects >=60 years of age.

Reduction of surgical-site infection in hip and knee arthroplasty: the influence of perioperative mupirocin nasal ointment and chlorhexidine soap in a double-blind, randomized, multicentre, placebo-controlled study.

The purpose of this study is to determine whether it is useful to decolonize patients undergoing primary hip or knee replacement surgery from the S. aureus skin bacteria.

Effect of Bacillus Calmette-Guérin vaccination on the immunogenicity of the mRNA BNT162b2 COVID-19 vaccine in health care workers

To determine the impact of prior BCG vaccination on the duration of immunogenicity of the BioNTech/Pfizer mRNA COVID*19 vaccine.

Timing and sequence of vaccination against COVID-19 and Influenza

Aim 1. To study the impact of different sequences of combined influenza and SARS-CoV-2 vaccinations on immunological responses and sideeffects.Aim 2. To understand the immunological mechanisms that mediate the potential interference between…

A double-blind, placebo-controlled randomized clinical trial with valsartan for PRevention of Acute rEspiraTORy dIstress syndrome in hospitAlized patieNts with SARS-COV-2 Infection Disease

To investigate the effect of the ARB valsartan in comparison to placebo on the occurrence of one of the following items, within 14 days of randomization:1) ICU admission; 2) Mechanical ventilation; 3) Mortality.

Bronchodilators for wheeze in young children presenting to primary care: a randomised, placebo-controlled, multicentre, parallel group trial.

What is the (cost-)effectiveness of salbutamol inhalations (4x200*g for 7 days) versus placebo in children aged 6-24 months presenting to their primary care physician with wheezing?

The effect of methenamine hippurate to reduce antibiotic prescribing due to new episodes of urinary tract infections (UTI) in elderly women with recurrent UTI- a triple-blinded, randomized placebo-controlled phase IV study

Primary objective: The primary objective of this study is to investigate if taking methenamine hippurate reduce the need for antibiotic usage due to recurrent UTI (measured as the number of courses of antibiotics).Secondary objectives:to investigate…

BCG-induced epigenetic modifications in the NEXT generation

To study the possible epigenetic modifications in sperm cells after BCG vaccination

Reducing hospital admission of elderly in SARS-CoV-2 pandemic via the induction of trained immunity by bacillus Calmette-Guérin vaccination, a randomized controlled trial.

Primary objective: To reduce clinically relevant respiratory tract infections (including COVID-19) ind community dwelling older persons during the pandemic of SARS-CoV-2. Secondary objective: To reduce disease severity, the duration of hospital…

The Perioperative ADministration of Dexamethasone and Infection trial

We plan to conduct a large, pragmatic, multicentre, randomised non-inferiority trial to determine whether the use of intraoperative dexamethasone, a widely used antiemetic in perioperative medicine, is associated with an unacceptable increased risk…