27 results
PRIMARY OBJECTIVE· 1. To study the effect of escitalopram versus placebo in the treatment of abdominal pain, in IBS patients with panic disorder.SECONDARY OBJECTIVES· 2.1. To assess the effect of escitalopram on gastrointestinal and psychiatric…
To assess the efficacy, safety, and pharmacokinetics of oral lubiprostone 12 or 24 mcg capsules dosed twice daily (BID) (based on subject body weight at baseline) as compared to matching placebo BID, when administered orally for 12 weeks in…
The objective of this clinical trial is to evaluate the tolerance and effectiveness of 4 week supplementation of a proprietary polydextrose fiber product, in a dose-ranging fashion, on whole gut transit time and gastrointestinal symptoms in adults…
To study the effect of fructo-oligosaccharides on functional constipation.
The primary objective is to evaluate the efficacy of prucalopride compared to placebo for the treatment of functional constipation in a paediatric population, aged *6 months to <18 years. Secondary objectives include:1. Investigation of the…
The effect of a specially developed multispecies probiotic on visceral perception, as well as on general symptom scores and inflammatory and microbiological parameters will be studied in a pilot study of IBS patients with an increased visceral…
The objectives of this study are to determine the safety and efficacy of IW-9179administered to patients with functional dyspepsia (FD), with and without concomitant protonpump inhibitor (PPI) administration.
see protocol summary
To assess the effect of amitriptyline on gastro-esophageal symptom severity and on esophageal sensitivity to acid perfusion and balloon distension in patients with documented functional heartburn.
1. Primary objective:To evaluate the efficacy of prucalopride versus placebo over 12 weeks of treatment in subjects aged 18 years and older with chronic non-cancer pain, suffering from OIC.2. Secondary objectives:To assess the safety and…
To study the safety and digestive tolerance of recombinant human Lactoferrin (rhLF) as expressed in milk of transgenic cattle.
The objectives of this exploratory trial are:1. To measure the pharmacodynamic (PD) effect on parameters derived from 24-hpH/impedance (MII) monitoring,2. To explore the effect on symptoms,3. To evaluate the safety and tolerabilityof treatment with…
To study the occurrence of postoperative ileus and the extend of the postoperative inflammatory response either systemic as well as locally in the bowel in patients receiving chewing gum before and after colorectal surgery.
The aim of the study is to investigate the surplus value of droperidol on top of het combination ondansetron and dexamethasone.
Investigate the effect of administration of CBD by means of CanChew® chewing gum versus a placebo on pain, IBS symptoms and perceived wellbeing in patients with IBS.
To assess the effect of Iberogast on heartburn, the incidence of reflux episodes and oesophageal sensitivity in patients with functional dyspepsia.
The aim of the Mint study is to investigate the effectiveness of peppermint oil capsules compared to placebo capsules in reducing abdominal pain intensity in these children. In addition, we investigate the effect of peppermint oil capsules compared…
The primary objective of this study is to determine the effect of short-term Turmipure GOLD® supplementation on LPS translocation in IBS-D and IBS-M patients after a high-fat challenge.The secondary objective of this study is to determine the effect…
To assess the effect of citalopram on symptoms of chest pain in patients with functional chest pain.
We want to examine the effect of the antihistamine Ebastine on abdominal pain and other symptoms associated with IBS and the quality of life. Through this research we would like to emphasize that this study primarily focuses on improvements of the…