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Does body satisfaction improve in adolescents with an eating disorder due to an online training based on evaluative conditioning?

The aim of this study is to investigate the effectiveness of a brief computer intervention to improve body satisfcation and self-esteem in a clinical population of adolescents with an eating disorder. We will examine whether the intervention is…

Effectiveness of Cognitive Remediation Training (CRT) and vocational rehabilitation (IPS), in persons with early psychosis.

The present study focusses especially on the value of cognitive skill training within a program of work integration by means of IPS. Research shows that these interventions indeed lead to enhanced cognitive skills (Wykes et al. 2011). According to…

A double blind, randomized, placebo controlled, cross-over study to validate the predictive power of the demarcation formula for Lybrido and Lybridos efficacy in women with female sexual interest/arousal disorder, in the domestic situation.

Primary Objective• To validate the existing demarcation formula (consisting of psychometric and biological markers) which predicts the sensitivity to Lybrido or Lybridos in women with female sexual interest/arousal disorder (FSIAD with or without…

An exploratory, blinded, randomized, placebo-controlled study in subjects with depressive disorder to investigate the effect of minocycline on relapse after successful intravenous ketamine/minocycline-induced (partial) symptoms response

Primary ObjectiveThe primary objective of this study is to assess whether the antidepressant response to IV ketamine can be maintained by minocycline compared to placebo.Secondary ObjectivesThe secondary objectives of this study are:* To investigate…

Mentalization-Based Treatment with and without Competitive Memory Training for patients with borderline personality disorder: randomnized controlled trial

The primary aim of the proposed study is to investigate whether adjunctive treatment of negative self-image with a specific intervention module (i.e. COMET) has added value in the treatment of patients with BPD compared with MBT without such a…

Single-Center, Randomized Single-Blind Placebo-Controlled Five-Arm Parallel Group Study to Assess Efficacy of a Single Dose of TBS-2 Intranasal Gel at Four Time Points Post-Dose using Vibrotactile Stimulation combined with Visual Sexual Stimulation in Female Subjects with Primary and Secondary Anorgasmia

This clinical trial is being performed to evaluate the efficacy of a single dose of TBS-2 on the occurence of orgasm. This study will explore the effect of TBS-2 on inducing an orgasm following sexual stimuli in anorgasmic female subjects at four…

UPFRONT - Prospective cohort study on early identification and treatment of adaptive deficits in mild to moderate traumatic brain injury - the impact of frontal network dysfunction for longterm outcome.

Objectives of the study: Project 1 - To assess early adaptive deficits in a multicentre cohort of mild to moderate TBI patients and their relation to outcome. Project 2 - Early intervention study of Cognitive Behavioural Therapy (CBT) to assess…

Attention Defficity Hyperactivity Disorder and fMRI neurofeedback: A randomized controlled trial on the effects of self-modulating anterior cingulate cortex activation levels.

The principal objective of this study will be to critically evaluate if the fMRI-neurofeedback training is successful in reducing ADHD symptoms and improving cognitive functioning. Thus, the first goal is to show that ADHD patients are able to…

Combining cognitive bias modification with rTMS: Evidence from a single session intervention in a dysphoric student population

The aim of this study is to test in a single session study in participants with subclinical depressive symptoms, whether adding ABM to rTMS treatment might maximize the beneficial effects on attentional bias, attentional control and emotional…

Cannabis as a cause of psychosis: An ecogenetic study linking cannabis-induced dopamine response to psychotic mechanisms and experiences

The following research questions are formulated:A. Does exposure to cannabis (THC) result in an increased dopamine response in the striatum (as measured with PET)? And does cannabis use lead to an increase in psychotic experiences or symptoms?B. Do…

Prevention of Health Care Workers* Health Problems after Work Related Critical Incidents: A Randomized Controlled Trial

Primary objective of the study is to test the effectiveness of two interventions (by comparison with a control intervention and by mutual comparison) in preventing the negative effects of critical incidents and chronic job demands on the outcomes:…

Attentional retraining with alcohol dependent patients

Decreasing AB and subsequent craving through attention training in alcohol dependent patients. Further, we will investigate whether the risk for relapse diminishes after the training. Long term goal is to investigate the effect of attention training…

A Study to Investigate Potential Interactions between GSK598809 and Ethanol in Healthy Subjects

Primary:* To investigate the safety and tolerability of the co-administration of GSK598809 at175 mg and ethanol in healthy volunteers.* To examine the potential pharmacokinetic interactions between GSK598809administered at 175mg and ethanol in…

A study to investigate the psychomotor and cognitive effects of alcohol when co-administered with GSK 1144814 or matching placebo in healthy subjects

To investigate whether the psychomotor and cognitive effects of alcohol are exacerbated by GSK1144814 in healthy subjects.

The effect of Transcranial Direct Current Stimulation (tDCS)
as an intervention to reduce violent behavior in forensic substance abuse patients.

The aim of this study is to investigate the effectiveness of tDCS in increasing empathy and reducing violent behavior in offenders with substance abuse problems.Through stimulation (and/or inhibiting) certain areas of the brain, tDCS causes a change…

EMDR treatment for anxiety related to the future in MS patients

The objective of this study is to examine whether EMDR with flashforward targets can be effective in reducing anxiety related to the future in MS patients. Specifically, following hypotheses will be examined: EMDR with flashforward target…

Imagery Rescripting with or without preceding Cognitive Restructuring: a randomized clinical trial

This research project examines whether there are differences in effects between application of ImRs preceeded by CR and ImRs as a stand-alone treatment technique on the so-called encapsulated beliefs, cognitive beliefs based on the aversive…

rTMS and cognitive control training in the context of depression

In this study, we want to combine rTMS and CCT to assess whether the combination of these two treatment would have synergistic effects and strengthen each other. We specifically want to assess the effect on mood and cognitive control, in a group of…

Advancing addiction treatment using neuromodulation: a rTMS enhanced CBT trial

The main objective of this study is to investigate whether rTMS add-on treatment will improve clinical outcomes in alcohol dependence. The secondary objective will be to answer the question through which mechanism rTMS will improve treatment…

Repetitive Transcranial Magnetic Stimulation (rTMS) versus sham rTMS in
Body Dysmorphic Disorder

The main objective of this study is to investigate whether rTMS treatment will improve clinical outcomes in body dysmorphic disorder, by reducing BDD YBOCS outcomes. Furthermore to improve localization and rTMS treatment in the dorsolateral…