55 results
This study has been transitioned to CTIS with ID 2024-516427-13-00 check the CTIS register for the current data. Substudy A: The primary objective will be to investigate the relationships between HPA axis dysfunction, early life adversity (ELA), and…
Primary: To investigate if CVL-865 decreases subjective anxiety symptoms elicited by a 35% CO2 inhalation challenge.Secondary: To investigate if CVL-865 decreases subjective fear symptoms elicited by a 35% CO2 inhalation challenge. To investigate if…
This study has been transitioned to CTIS with ID 2024-514783-78-00 check the CTIS register for the current data. The aim of this project is to investigate CBD as a new medicine to target the ECS in the reduction of anxiety symptoms. Subsidiary aims…
Primary objective: Our key objective is to determine if a cannabinoid manipulation is more effective than a glucocorticoid manipulation to facilitate fear memory extinction retention in an experimental model of exposure therapy in healthy…
The aim of this experiment is to determine the differential effects of noradrenaline and cortisol on memory accuracy versus generalization and to investigate the divergent effects of these stress mediators on the neural mechanisms underlying the…
We aim to fill the gap between the 50% of patients helped by standard therapies (ERP with/without SSRIs) and the 1% receiving surgery by using a non-invasive alternative: repetitive transcranial magnetic stimulation (rTMS) to potentiate the effects…
The primary objective of this study is to identify the distinct roles of the peripheral and central nervous system in the subjective experience of panic.
To test whether tACS in a theta frequency enhances extinction of physiological stress responses to exposure to anxiety- or trauma-related stimuli or memories. Secondarily, to examine the influence of baseline neuroendocrinological response, baseline…
We aim to lay the fundament of novel interventions by gaining an in-depth comprehensive understanding of individual differences in the overnight adaptation of emotional memory and malleability thereof by noradrenergic modulation.
Our aim is to test whether disrupting the process of fear memory reconsolidation is an effective as well as efficient intervention for patients with panic disorder. A secondary aim is to test whether the expected reduction in panic attacks and…
The objective of this study is to examine whether EMDR with flashforward targets can be effective in reducing anxiety related to the future in MS patients. Specifically, following hypotheses will be examined: EMDR with flashforward target…
The primary objectives are:- To investigate the safety and tolerability of JNJ-61393215 after multiple consecutive dose administrations;- To characterize the pharmacokinetics (PK) of JNJ-61393215 in plasma after multiple consecutive dose…
This study will be performed in 56 healthy volunteers. The study will be performed in 3 parts, Part 1, Part 2 and Part 3. Part 1 will be performed in 16 healthy volunteers divided over 2 groups of 8 volunteers each. The purpose of Part 1 of the…
To test within an anxiety and aggression patient sample the effect of a tDCS intervention on (i) task-specific inhibitory control, and (ii) threat and implicit inhibitory control, attention bias and anxiety and aggression symptom reduction in a…
The properties of CBD, namely potential effects on variables pertaining to fear extinction and potentially on fear retention/reinstatement while having non of the problematic side-effects found in *9-THC, make CBD plausibly preferential over *9-THC…