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A randomized, double-blind, placebo-controlled, pilot trial of probiotics in pregnant women with symptoms of anxiety and depression.

The primary objective is to assess feasibility of a food supplement (multispecies probiotic) placebo-controlled, randomised controlled, double blind intervention in pregnant women in their late second/third trimester of pregnancy, to reduce symptoms…

Deep brain stimulation of the medial forebrain bundle for patients with treatment-resistant depression

Establishing efficacy of MFB DBS for TRD by comparing active DBS with sham DBS. Secondary aims are establishing an adverse events profile, establishing effects on quality of life, cost-effectiveness, (neuro)psychological and neuroimaging measures.

Precision psychiatry: Anti-inflammatory medication in Immuno-metabolic depression

This study has been transitioned to CTIS with ID 2024-513907-15-01 check the CTIS register for the current data. Among patients under treatment for depression, we will select 140 persons with IMD. In this specific group of patients, we will test…

SAMe as an epigenetic treatment of depression in people with childhood trauma, a double blind placebo-controlled trial

Primary objective is to compare changes in depression ratings in patients with childhood trauma receiving SAMe with patients receiving a placebo over a 12 week follow-up period. A number of secondary objectives will be investigated: 1. Comparing the…

A randomised controlled trial of oral S-ketamine as add-on medication for patients with treatment-resistant major depressive disorder

The proposed study aims to examine the antidepressant efficacy of oral S-ketamine augmentation in patients with TRD treated with regular antidepressants in a double-blind randomised controlled trial. Secondary questions involve the effects of oral S…