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Light Therapy for better Mood and Metabolic control:
a randomised double-blind placebo-controlled clinical trial in patients with Type 2 Diabetes Mellitus and Depression

(1) To investigate the efficacy of LT in patients with T2DM and comorbid depression, and (2) whether LT leads to improved insulin sensitivity, and (3) whether effects on mood and metabolic control are mediated by restoration of the circadian…

Bright up! A randomized, double-blind, placebo-controlled study of light therapy for depression during pregnancy.

To investigate whether bright light therapy is an effective treatment for depression during pregnancy compared with low-intensity placebo light therapy (proof-of-principle) and to investigate the late effects of bright light therapy versus placebo…

Investigating the role of rTMS in the treatment of chronic depression

(1) To investigate the effect of rTMS in a treatment set-up of 4 weeks including sham-rTMSas a control in 2 x 50 patients who have had at least two prior antidepressant therapies and psychotherapy according to the Dutch guideline of depression.(2)…

An exploratory, multicenter, placebo-controlled, randomized, double-blind study to investigate the antidepressant mechanism-of-action of JNJ-42847922 in subjects with major depressive disorder.

To investigate the effect of JNJ-42847922 given as monotherapy as compared to placebo on symptoms of depression in male and female MDD patients

Vitamin D and non-specific musculoskeletal complaints in non-Western immigrants

We aim to assess the effect of high-dose vitamin D supplementation on non-specific musculoskeletal complaints in non-Western vitamin D-deficient immigrants and to determine whether improvement of mood is associated with this effect.

An exploratory, blinded, randomized, placebo-controlled study in subjects with depressive disorder to investigate the effect of minocycline on relapse after successful intravenous ketamine/minocycline-induced (partial) symptoms response

Primary ObjectiveThe primary objective of this study is to assess whether the antidepressant response to IV ketamine can be maintained by minocycline compared to placebo.Secondary ObjectivesThe secondary objectives of this study are:* To investigate…

A Randomized, Double-Blind, Placebo-Controlled, 2-Period Crossover Study to Evaluate the Effect of Intranasal Esketamine on Cognitive Functioning in Healthy Subjects

To evaluate the effect of intranasal esketamine 84 mg on cognition, and duration of cognitive effects (if present), as assessed using a computerized test battery (Cogstate®).

Effect of bright light on mood and sleep in Parkinson's disease

The primary aim of this study is to measure the effect of light therapy on mood in depressed Parkinson patients. In addition, we measure the effect of light therapy on sleep, motor functions, circadian rhythms and quality of life.

A single dose, 4-way crossover, double-blind, placebo-controlled, randomized study to investigate the effect of JNJ-42847922 on polysomnography (PSG) measures in subjects with major depressive disorder with insomnia who are stably treated with antidepressants.

Primary ObjectiveTo evaluate the effect of JNJ-42847922 on sleep latency (latency to persistent sleep [LPS]) in MDD subjects, stably treated with an SSRI/SNRI, who suffer from insomnia.Secondary Objectives* To investigate the safety, tolerability,…

A Double-blind, Randomized, placebo-controlled, 3-way crossover study to eValuate the single dose Effects of Intranasal eSketamine on saFety of on-road driving in healthy subjects(DRiVE SaFe)

The objective of this study is to investigate whether subjects who have taken esketamine, will be able to drive a car as soon as their cognitive function has been restored. The residual effects on driving performance will be compared to placebo.…

Cost effectiveness of augmented cognitive behavioural therapy for post stroke depression and anxiety

Our main objective is to investigate whether an augmented CBT leads to the reduction of depression and anxiety symptoms in stroke patients. We will compare the outcomes of this experimental treatment with a control intervention (i.e., computerized…

Tackling depressive disorder: A working memory intervention

The present study is aimed at investigating cognitive underpinnings of depression, by focusing on working memory abilities in both depressed and non-depressed individuals. These findings will be employed to design and test a therapeutic intervention…

Treatment of depressive symptoms with mood induction

In the current study the effectivity of positive visual stimuli in improving mood and reducing depressive symptoms is examined. In addition, in order to see if the effects are persistent, mood is re-assessed in a 3 month follow-up session.

The effects of ARA290 on the cognitive and neural processing of emotions in healthy volunteers

To study the effects of ARA290 on the cognitive and neural processing of emotions in healthy volunteers 7 days post-administration.

A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, SINGLE ASCENDING DOSE STUDY TO EVALUATE SAFETY, TOLERABILITY, PHARMACOKINETIC AND FOOD EFFECT OF BCI 838 AND AN OPEN-LABEL MINIDOSE BIOAVAILABILITY STUDY TO COMPARE SEVERAL BCI-632 PRO-DRUG CANDIDATES IN HEALTHY MALE SUBJECTS

- to evaluate the safety and tolerability of BCI-838 following oral administration of single doses of BCI-838 in healthy male subjects- to determine the pharmacokinetics of BCI-838 and metabolite BCI-632 following oral administration of single…

An eight-week, multinational, multicenter, double-blind, active- and placebo-controlled clinical trial evaluating the efficacy and tolerability of three fixed doses of SSR125543 (20mg daily, 50 mg daily and 100 mg daily) in outpatients with major depressive disorder.

The objective of the study is to evaluate various doses of SSR125543 in first patients (outpatients with a major depressive disorder), evaluate collected information concerning tolerability, efficacy en safety. The same infomation will be evaluated…

Transcranial Magnetic Stimulation in depression treatment

Finding out if adjustment of intensity and duration of rTMS stimulation will produce a more robust antidepressant effect.

The effect of fludrocortisone on emotional information processing in healthy volunteers

To investigate the effects of a single dose of fludrocortisone, a mineralocorticoid receptor agonist, on emotional information processing in healthy female participants.

Combining cognitive bias modification with rTMS: Evidence from a single session intervention in a dysphoric student population

The aim of this study is to test in a single session study in participants with subclinical depressive symptoms, whether adding ABM to rTMS treatment might maximize the beneficial effects on attentional bias, attentional control and emotional…

A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, ASCENDING MULTIPLE DOSE, SAFETY, TOLERABILITY PHARMACODYNAMIC AND PHARMACOKINETIC STUDY OF BCI 838 IN HEALTHY ADULT SUBJECTS

Primary: To evaluate the safety and tolerability following oral administration of multiple doses of BCI-838 in healthy male and female subjects Secundary:To determine the pharmacokinetic profile of multiple oral doses of BCI-838 in healthy male and…