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Study of Safety, Tolerability, and Pharmacokinetics of BG00010 (Neublastin) Intravenous and Subcutaneous Single Ascending Doses in Healthy Volunteers, and Subcutaneous Multiple Ascending Doses in Subjects with Painful Lumbar Radiculopathy

The primary objective of the study is to evaluate the safety and tolerability of a range of single IV and SC doses of BG00010 in healthy volunteers, and a range of multiple SC doses of BG00010 in subjects with painful lumbar radiculopathy.Secondary…

A Multi-Centered, Randomized, Blinded, Placebo-Controlled, Serial-Cohort, Multiple Ascending Dose Study of the Safety, Tolerability, Pharmacokinetics and Efficacy of BG00010 (Neublastin) in Subjects with Sciatica

The primary objective of the study is to evaluate the safety, tolerability, and pharmacokinetic (PK) profile of 3 intravenous (IV) injections of BG00010 given on 2 fixed schedules; weekly and as frequently as every 48 hours (but no more than 3 times…

A randomised, sham-controlled, double-blind, multicenter clinical trial to evaluate the percutaneous pulsed radiofrequency treatment at the dorsal root ganglion

investigate the value of percutaneous pulsed radiofrequency, applied to the lumbar and sacral dorsal root ganglion; more specifically try to determine if a significant and long lasting pain reduction can be obtained as compared to a sham-operated…

A placebo-controlled, randomized, safety and efficacy study of BOTOX® (Bolulinum Toxin Type A) Purified Neurotoxin Complex in patients with neurogenic detrusor overactivity and neurological respiratory impairment.

To evaluate the safety and efficacy of 2 dose levels of BOTOX® (200 U or 300 U) compared to placebo injected into the detrusor for the treatment of urinary incontinence caused by neurogenic detrusor overactivity in patients who have not been…

Study of the analgesic effects of repeated doses of F13640 in spinal cord injury patients with moderate to severe central neuropathic pain.
A multinational, multicenter, randomized, double blind, parallel groups, placebocontrolled
study.

Primary objective:To evaluate the efficacy of F13640 in spinal cord injury patients with moderate to severe central neuropathic pain, when administered for 12 weeks including a 7-day titration period. Main secondary objectives:To evaluate pain…

The efficacy of the IDD-protocol with Accu-Spina for patients with low back pain

The primary objective of the study is to investigate whether the IDD (Intervertebral Differential Dynamics) protocol with Accu-Spina on the VAS low back pain score at 3 months posttreatment.

A randomized, placebo-controlled, double-blind, single ascending dose study to evaluate the safety, tolerability and pharmacokinetics of NX210 in healthy volunteers.

Primary objective:To assess the safety and tolerability of single doses of i.v. administered NX210.Secondary objective:To assess the PK of NX210 via its metabolite NX210c in plasma after single doses of i.v. administered NX210.Exploratory objectives…

Multiple dose safety, tolerability, plasma and cerebrospinal-fluid pharmacokinetic study of oral doses of CORT113176

In this study we will investigate how safe the new compound CORT113176 is and how well it is tolerated when it is used by healthy participants.We also investigate how quickly and to what extent CORT113176 is absorbed, transported, eliminated from…

A Phase 2a Study of TPN-101 in Patients with C9ORF72 ALS/FTD (Amyotrophic Lateral Sclerosis and/or Frontotemporal Dementia)

The primary objective of this study is:* To assess the safety and tolerability of TPN-101 in patients with C9ORF72 ALS/FTDThe exploratory objectives of this study are:* To assess the concentrations of TPN-101 in plasma and cerebrospinal fluid (CSF…

A multicenter, prospective, randomized, placebo-controlled, double-blind, parallel-group clinical trial to assess the efficacy and safety of Immune Globulin Intravenous (Human) Flebogamma® 5% DIF in patients with Post-Polio Syndrome

To test whether monthly infusions (every four weeks) of intravenous Flebogamma® 5% DIF in a 1 year treatment period in PPS subjects are superior to placebo by assessing physical performance, as measured by 2MWD.For Stage 1, to select the optimal…

A Randomised, Double-Blind, Placebo-Controlled, Single- and Multiple-, Ascending-Dose Study of the Safety, Tolerability, and Pharmacokinetics and Pharmacodynamics of VRG50635 and Food Effect in Healthy Volunteers (Phase 1a)

Part 1; Single ascending dose (main objective)• To investigate the safety and tolerability of single oral doses of VRG50635 in healthy adult subjectsPart 1; Single ascending dose (secondary objective)• To characterize the plasma and urine…

A Randomized, Placebo-Controlled, Double-blind, Single Ascending Dose, First in Human Phase 1 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of QRL-101 in Healthy Participants.

In this study we will investigate how safe the new compound QRL-101 is and how well it is tolerated when it is used by healthy subjects. A single dose of the study compound will be given to each participant. We will also investigate how quickly and…

The use of pectoral nerve block type II in patients undergoing trans-axillary thoracic outlet decompression.

To be able to further investigate the benefit of these interfascial plane blocks we want to perform a randomized controlled trial. Since the effect on postoperative pain of PECS II was similar to PECS I + ESB, we only use the PECS II as an…

a Randomized controlled trial for epidural Analgesia for Pain relief after lumbar Interlaminar Decompressive spine surgery - RAPID

To determine whether intraoperative epidural analgesia is superior to placebo in reducing wound pain in patients after decompressive lumbar spine surgery, and to determine whether opioid use in the 2 days after surgery is significantly higher in the…

A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of BIIB074 in Subjects With Neuropathic Pain From Lumbosacral Radiculopathy

The primary objective of the study is to evaluate the efficacy of 2 dose regimens of BIIB074 on neuropathic pain in subjects with PLSR.A secondary objective is to evaluate the efficacy of 2 dose regimens of BIIB074 on additional neuropathic pain…