755 results
Primary Objective: To prove the hypothesis that Intradiscal Methylene blue is capable of longer pain reduction and better global perceived effect in patients suffering from chronic axial low back pain from discogenic origin then a placebo treatment…
To assess (i) the effect of partial neuromuscular blockade (NMB; TOF ratio 0.7) induced by low-dose rocuronium on the ventilatory response to isocapnic hypoxia and (ii) the effect of the reversal by sugammadex, neostigmine or placebo in healthy…
In this study the best treatment of DSPS will be investigated by comparison of existing treatments. We will investigate is patients with ADHD and DSPS have less favorable blood values for biomarkers of chronic diseases in comparison with norm values…
To assess, in patients with non-specific low back pain, lasting for over 3 months, the effect of two doses of olpadronate administered intravenously on low back pain as compared to placebo treatment. Assessment of safety and tolerability are also…
To assess the efficacy and safety of 2 dose levels of NTRA-2112 on intestinal malabsorption in preterm infants as compared to placebo.The sub-study aims to determine whether NTRA-2112 in own mother's milk, donor human milk or preterm formula…
The purpose of this study is to investigate how safe the new compound NPT189 is when it is administered to healthy subjects. NPT189 has not been administered to humans before. It has been previously tested in the laboratory and on animals. NPT189…
The purpose of our study is to test the effect of a computer-based cognitive behavioral intervention (called Cognitive Bias Modification, CBM) on affective symptoms in oncology patients. Here we are collaborating with the Oncology department of the…
1) To evaluate the pain, acceptability and local tolerability of intradermal microneedle injection compared to subcutaneous injection in healthy volunteers.2) To evaluate the safety, pharmacokinetics, pharmacodynamics, and immunogenicity of…
1. To evaluate the safety and tolerability of ascending multiple oral doses of HTL18318 in healthy adult male and female subjects.2. To evaluate the pharmacokinetics of ascending multiple oral doses of HTL18318 in healthy adult male and female…
This research project examines whether there are differences in effects between application of ImRs preceeded by CR and ImRs as a stand-alone treatment technique on the so-called encapsulated beliefs, cognitive beliefs based on the aversive…
The purpose of this study is to investigate how safe the new compound BAY 1213790 is and how well it is tolerated when it is administered as an injection under the skin to healthy male volunteers. BAY 1213790 has been administered to humans before.…
Objectives: To investigate the effect of a daily sachet of probiotics on vitamin K status for 12 weeks vs placebo.
This pilot study aims to assess the feasibility, safety and preliminary efficacy of a novel thermosensitive hyaluronic acid gel with an octenidine preservative system as an adjunct to standard non-surgical periodontal treatment. The use of a blinded…
The primary objective is to evaluate the effectiveness of dietary nitrate in reducing muscle atrophy induced by bedrest. Secondary objectives include assessing its impact on insulin resistance, muscle strength, and cardiovascular function.…
Primary Objective: To assess the acute subjective drug effects (good/bad drug effect, drug liking/wanting, anxiety), cognition (attention, working memory, information processing speed, verbal memory, verbal fluency, motor inhibition), and…