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Levothyroxine for euthyroid women with recurrent miscarriage and positive TPO antibodies: a randomized controlled trial

First objective: To assess improvement in live birth rate after levothyroxine supplementation. Secondary objective: 1) to test the hypothesis that levothyroxine lowers the risk for miscarriage and preterm birth 2) to test the hypothesis that…

Vitamin D And Lifestyle Intervention for Gestational Diabetes Mellitus (GDM) Prevention - A European multicentre, randomised trial: Vitamin D limb.

The overall aim of the DALI study is to identify the best available measures to prevent GDM in an ongoing pregnancy, to provide a cost-benefit calculation of GDM prevention for health care systems, and to establish a pan-European cohort of mother-…

Does antenatal allopurinol during perinatal asphyxia reduce post-hypoxic-ischemic reperfusion damage in the newborn? A double blind randomised placebo controlled multicenter trial.

In the present proposal, we aim to answer whether antenatal allopurinol administration does reduce hypoxic-ischaemic encephalopathy in neonates exposed to intra-uterine asphyxia.

A randomized clinical trial to study the effect of vitamin D supplementation on insulin sensitivity in Gestational Diabetes Mellitus

The main objective is to study the effect of vitamin D supplementation on insulin sensitivity in patients with gestational diabetes mellitus.

Immune effects of acidic and neutral oligosaccharides in the nutrition of preterm infants.

Investigate the effect of acidic and neutral oligosaccharides supplemented enteral nutrition on infectious morbidity, feeding tolerance and short-term outcome in VLBW infants. Furthermore, an attempt is made to elucidate the role of acidic and…

First trimester progesterone therapy to reduce miscarriages in women with a history of unexplained recurrent miscarriages: A randomised, double blind, placebo-controlled, multi-centre trial.

To test the hypothesis that in women with unexplained recurrent miscarriages, progesterone started as soon as possible after a positive pregnancy test ) and continued to 12 weeks of gestation, compared to placebo, increases live births beyond 24…

Leiden's IVIg trial in Rhesus disease of the Neonate

AimTo determine whether the prophylactic use of IVIg reduces the need for ET in neonates with Rh-D hemolytic disease.

Effect of folic acid supplementation in pregnancy on preeclampsia - Folic Acid Clinical
Trial (FACT)

Primary ObjectiveThe overall aim is to evaluate a new preeclampsia (PE) prevention strategy: 4.0mg (1.0mg x 4) of folic acid supplementation vs. placebo from early (80/7 to 166/7 weeks of gestation) pregnancy until delivery.Secondary ObjectivesTo…

Darbepoetin for Ischemic Neonatal Stroke to Augment Regeneration

This study has been transitioned to CTIS with ID 2024-513042-12-01 check the CTIS register for the current data. To perform a double-blind randomized placebo controlled multicenter study with darbepoetin in infants with MRI confirmed PAIS and to…

A pilot study assessing the feasibility of a randomized controlled trial evaluating aspirin in postpartum women at risk of developing venous thromboembolism

The purpose of this pilot trial is to determine whether it is feasible to conduct a full multicentre randomized controlled trial (RCT) to determine whether low-dose aspirin (ASA) is efficacious and safe at preventing postpartum venous…

Low dose aspirin in the Prevention of Recurrent Spontaneous Preterm Labour

To assess the effectiveness of low dose aspirin compared with placebo in prevention of recurrent spontaneous preterm birth.

Aspirin for the prevention of spontaneous preterm birth

The objective was to assess the effectiveness of low-dose aspirin in the prevention of recurrent preterm birth.