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Addition of Tobramycin inhalation antibiotic treatment to standard IV antibiotic treatment for ventilator-associated pneumonia

Does addition of inhalation tobramycin to standard IV treatment result in a higher clinical cure rate than standard IV antibiotic treatment alone in patients with ventilator-associated pneumonia.The initial response to treatment will be evaluated…

Effect of Carbon Nanoparticles on Inflammation and Coagulation after Bronchial Segmental Instillation. A dose escalation study

We will investigate the local and systemic effects of carbon nanoparticles on inflammation and coagulation in humans by bronchial segmental challenge

Cognitive and emotional effects of sleep apnea and its rehabilitation in stroke patients

In this study the effect of SAS and the treatment with CPAP on cognitive functioning, fatigue and mood in stroke patients will be investigated. The main research questions are: 1) Is there a relationship between (the severity of) SAS and cognitive…

The effect of two dosing regimens cefotaxime on the presence of potential pathogenic micro-organisms in airways.

Is treatment A: cefotaxime parenteral twice daily 1 gram during four days as effective as treatment B: cefotaxime parenteral four times daily 1 gram in preventing airway colonisation by potential pathogenic microorganisms.

Effect of intrapulmonary administration of recombinant human activated protein C on local coagulation and inflammation after bronchial instillation of lipopolysaccharide in humans

The primary objective is to determine the effect of locally administered rhAPC on LPS-induced lung inflammation and coagulation. By using measurements on cells harvested from bronchoalveolar lavage (BAL)-fluid and in BAL-fluid supernatants, we will…

A prospective study to evaluate the safety and efficacy of AdvaCoat Mx sinus gel for treatment of chronic rhinosinusitis without nasal polyps.

The purpose of the first part of the study is the evaluation of the first 9 subjects that will be conducted to confirm the 1.5 mL AdvaCoat Mx treatment volume per side as the desired volume for the expanded portion of the study. The purpose of the…

Timing and sequence of vaccination against COVID-19 and Influenza

Aim 1. To study the impact of different sequences of combined influenza and SARS-CoV-2 vaccinations on immunological responses and sideeffects.Aim 2. To understand the immunological mechanisms that mediate the potential interference between…

Respiratory muscle training in patients with Spinal Muscular Atrophy

The aim of this study is to assess the feasibility and efficacy of respiratory muscle training (RMT) in patients with SMA and respiratory muscle weakness.

Single dose escalation study in a single-center, randomized, single-blind, placebo-controlled, group-comparison design to investigate pharmacokinetics, safety and tolerability of BAY 2586116 after intravenous administration in healthy male participants.

The purpose of this study is to investigate how quickly and to what extent the study compound BAY 2586116 is absorbed and eliminated from the body. It will also be investigated how safe the new compound BAY 2586116 is and how well it is tolerated…

Development of a *two hit* in vivo autologous platelet transfusion model in healthy volunteers

To develop a *two hit* in vivo autologous PLTs transfusion model in healthy male volunteers