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Respiratory infections in asthma: the role of host defense against infections, allergic inflammation and vitamin D

We hypothesize that local AMPs expression in the airways of patients with asthma is decreased as a result of allergic inflammation. Furthermore, we hypothesize that local AMP expression can partly be restored by vitamin D substitution therapy. We…

The effect of tiotropium-bromide on deep inspiration-induced bronchodilation and airway responsiveness in asthma.

1) To examine the effect of 3 weeks of 18*g tiotropium bromide once daily on the degree of bronchodilation following deep inspiration at a given level of bronchoconstriction.2) To examine the effect of 3 weeks of 18*g tiotropium bromide once daily…

The effect of treatment with high dose vitamin D on airway inflammation in non-atopic asthma.

Primary Objective: To investigate the effect of supplementation of a single high dose of vitamin D (400.000 IU) on 1. the percentage of neutrophils in induced sputum, in non-atopic asthmatic patients with neutrophilic airway inflammation (…

Effect of palivizumab on respiratory syncytial virus-associated burden of disease - a randomized controlled trial

It is not known whether recurrent wheeze in preterm children is caused by RSV infection (serial hypothesis) or that RSV infection is the first indication of chronic airway morbidity that would develop anyway (parallel hypothesis). This study aims to…

A Cross-over Randomized Controlled Trial; Pulmonary edema detection after fluid loading with blood versus saline in patients after CABG

Cardiac surgery patients are often exposed to blood products perioperatively (18). Due to their underlying cardiac condition and ventricular dysfunction these patients are at an increased risk for TACO.(19) In a *proof of principle* approach we will…

A randomized, double-blind, placebo-controlled study to compare the immune effects of multiple doses of vitamin D3 in patients with allergic rhinitis/rhino-conjunctivitis caused by birch pollen and in healthy control subjects.

The primary objective is to evaluate whether 2.5 µg VD3 analogue (Zemplar® * Abbvie) in multiple subcutaneously administered doses induces a more favourable (read: anti-inflammatory) systemic immune modulation both in general parameters and allergen…

The role of dynamic hyperinflation in asthma

Primary objective: To investigate the effect of supplementation of a single intramuscular dose of 80 mg triamcinolone on the level of MPT-induced dynamic hyperinflation, in adult asthma patients with demonstrated dynamic hyperinflation. (Part 1)…

Development of a *two hit* in vivo autologous platelet transfusion model in healthy volunteers

To develop a *two hit* in vivo autologous PLTs transfusion model in healthy male volunteers

The PHENOSAR trial: Antibiotic treatment of biopsy confirmed phenotypes in sarcoidosis: a proof of concept clinical trial

This study has been transitioned to CTIS with ID 2024-513534-38-00 check the CTIS register for the current data. Investigate whether treatment with azithromycin has an inhibitory effect on the mTOR pathway and/or C. acnes, causing a reduction of the…