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Re-integration Study Xentix

To reduce stress-related problems and increases reintegration of work, the company Letec developed a technique that utilizes the light therapy / magnetic therapy treatment platform Xentix besides coaching. In order to demonstrate the effectiveness…

Cyclopentolate induced EEG changes in children

To compare the EEG pattern after administration of cyclopentolate with the EEG pattern after placebo eye-drops.Primary outcomeEEG pattern changes after administration of two drops of cyclopentolate1% compared with placebo.Secondary outcomes- Pattern…

The effect of uterine bathing on implantation in endometriosis patients undergoing IVF/ICSI: a randomized controlled pilot trial

To evaluate the effect of uterine bathing in improving the results of IVF/ICSI treatment in patients with endometriosis ASRM stage I-IV.

Does body satisfaction improve in adolescents with an eating disorder due to an online training based on evaluative conditioning?

The aim of this study is to investigate the effectiveness of a brief computer intervention to improve body satisfcation and self-esteem in a clinical population of adolescents with an eating disorder. We will examine whether the intervention is…

Effectiveness of Cognitive Remediation Training (CRT) and vocational rehabilitation (IPS), in persons with early psychosis.

The present study focusses especially on the value of cognitive skill training within a program of work integration by means of IPS. Research shows that these interventions indeed lead to enhanced cognitive skills (Wykes et al. 2011). According to…

A randomized, 2-part, placebo controlled phase 1 study to evaluate safety, tolerability, pharmacokinetics and immunogenicity following single ascending doses (Part 1) and multiple ascending doses (Part 2) of GBR 830 in adult healthy subjects

The purpose of the study is to investigate to what extent GBR 830 is tolerated. It will also be investigated how quickly and to what extent GBR 830 is absorbed and eliminated from the body (this is called pharmacokinetics). In addition, the effect…

A Phase 1, Randomized, Blinded, Placebo-Controlled, Dose-Ranging Study of MVT-602 in Healthy Premenopausal Women

PrimarySafety and tolerability of MVT-602 following single dose subcutaneous administration in healthy premenopausal womenSecondaryPharmacokinetics (PK) and pharmacodynamics (PD) of MVT-602 following single dose subcutaneous administration

BLUE LIGHT THERAPY FOR SLEEP IMPAIRMENT IN PARKINSON*S DISEASE - Pilot Study -

1. Primary Objective:The primary objective is to evaluate the efficacy of Propeaq light therapy glasses with integrated blue LED lights on sleep disorders in patients with PD using the PSQI. 2. Secondary Objectives: The secondary objective of the…

A randomized, controlled, single-blinded, multicenter clinical trial to evaluate the percutaneous radiofrequency treatment of facet joint pain versus a sham-operated group

Investigate the value of percutaneous radiofrequency heat lesion, applied to the medial branch of the primary dorsal ramus; more specifically try to determine if a significant and long lasting pain reduction can be obtained as compared to a sham-…

A randomized, controlled, single-blinded, multicenter clinical trial to evaluate the percutaneous radiofrequency treatment of discogenic pain at the ramus communicans versus a sham-operated group

Investigate the value of percutaneous radiofrequency heat lesion applied to the ramus communicans; more specifically try to determine if a significant and long lasting pain reduction can be obtained as compared to a sham-operated group. In addition…

An exploratory, blinded, randomized, placebo-controlled study in subjects with depressive disorder to investigate the effect of minocycline on relapse after successful intravenous ketamine/minocycline-induced (partial) symptoms response

Primary ObjectiveThe primary objective of this study is to assess whether the antidepressant response to IV ketamine can be maintained by minocycline compared to placebo.Secondary ObjectivesThe secondary objectives of this study are:* To investigate…

Intermanual transfer using mental imagery in prosthetic training

The objective of this study is to determine the surplus value of mental imagery on myo-electric prosthesis training Here fore we plan to execute two experiments. The goal of the first experiment is to test if intermanual transfer effects of able-…

Mentalization-Based Treatment with and without Competitive Memory Training for patients with borderline personality disorder: randomnized controlled trial

The primary aim of the proposed study is to investigate whether adjunctive treatment of negative self-image with a specific intervention module (i.e. COMET) has added value in the treatment of patients with BPD compared with MBT without such a…

Alcohol and Oxycodone - The influence of the combination of alcohol and an opioid on ventilation in healthy young and elderly volunteers - the 'A&O' study

In the current study we will measure ventilatory response, as assessed by ventilatory carbon dioxide responses to the administration of oxycodone during three conditions: a *low alcohol condition*, a *high alcohol condition* and a *no alcohol…

Addition of Tobramycin inhalation antibiotic treatment to standard IV antibiotic treatment for ventilator-associated pneumonia

Does addition of inhalation tobramycin to standard IV treatment result in a higher clinical cure rate than standard IV antibiotic treatment alone in patients with ventilator-associated pneumonia.The initial response to treatment will be evaluated…

Helium induced organ protection and the role of circulatory factors:
secretion of Caveolin to the bloodstream (HeCav) in humans.

The primary objective of this study is to investigate whether serum taken from volunteers subjected to 30 minutes of helium inhalation can protect different cell types against hypoxia-reperfusion induced damage and to investigate the role of…

A prospective, randomized, cross-over, single-blind, placebo-controlled study to assess the pharmacodynamic effects, pharmacokinetics and safety and tolerability of one dose of 30 mg ulipristal acetate (UPA) followed by the administration of 20 days of 75 µg desogestrel (DSG)

The aim of the present study is to assess the contraceptive potential of the association of UPA 30 mg single dose and desogestrel 75 micrograms for 20 days. The study will also assess the potential possible interaction, (in terms of ovarian activity…

A phase I, single-centre, randomised, single-blinded, placebo-controlled single ascending dose study, followed by an open-label extension, evaluating the safety, pharmacokinetics, pharmacodynamics and efficacy of ALX 0651, administered intravenously to healthy male volunteers.

The objectives of this study are to:* To establish the safety and tolerability of ALX 0651, administered i.v. to healthy volunteers.* To investigate the pharmacokinetics of ALX 0651, administered i.v. to healthy volunteers.* To investigate the…

A Single blind, Placebo controlled, Phase I Dose-ranging Study to Evaluate the Activity of SRT2379 on Endotoxin induced Inflammatory Response in Healthy Male Subjects

Primary objective: To determine if a single administration of SRT2379, at multiple dose levels, attenuates the inflammatory response in normal healthy male subjects after exposure to low-dose endotoxin (LPS)Secondary objectives: (1) To determine…

Effect of Carbon Nanoparticles on Inflammation and Coagulation after Bronchial Segmental Instillation. A dose escalation study

We will investigate the local and systemic effects of carbon nanoparticles on inflammation and coagulation in humans by bronchial segmental challenge