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Desensitisation of ulcerative colitis patients intolerant for mesalazine treatment.

Primary endpoint:- Successful desensitization for Mesalazine in ulcerative colitis patients with a presumed history of intolerance for Mesalazine. Secondary endpoint:- To investigate if a presumed intolerance for Mesalazine may be reproducible in a…

*Evaluation of the effect of probiotics on development of asthma and allergic rhinitis during childhood - follow-up study at age 5 or 6 years*

Objective: To establish the effect of perinatal probiotics on the prevalence of allergic disease at the age of 5 or 6 years.

A phase I, mono-center, placebo and comparator controlled, single-blind, randomized, parallel group, clinical study to determine multiple dose safety, tolerability, pharmacokinetics, and pharmacodynamics of FSH-GEX* administered subcutaneously in healthy pituitary-suppressed female volunteers

- To assess the safety and tolerability of FSH-GEX* following multiple dose administration by subcutaneous injection- To determine the pharmacokinetic profile of FSH-GEX* following multiple dose administration by subcutaneous injection- To assess…

Post prandial muscle perfusion and protein metabolism in healthy young and elderly men

The primary objective of the study is to investigate whether local insulin supplementation augments the in vivo postprandial muscle protein synthetic response after protein ingestion and whether this response is differs between young and elderly…

Navigation ability after stroke

Primary objective: To create diagnostic and treatment tools for navigation ability in stroke patients, that can be used in clinical practice.Secondary objective: To increase knowledge about the cognitive structure and neuroanatomical correlates of…

Application of mesenchymal stem cells in patients with end-stage renal disease

The primary objective of the study is:- to establish the safety and feasibility of infusion of escalating doses of autologous ASC in end-stage renal disease patients. Secondary objectives are:- to determine the effect of ASC infusion on kidney…

Randomized, single-blind, placebo controlled multicenter phase III study to assess the efficacy and safety of expanded autologous adipose-derived stem cells (eASCs) (CX-401), for treatment of complex perianal fistulas in Crohn*s disease.

The primary objective of the study is to evaluate the efficacy of intralesional administration of eASCs (CX-401) when added to standard surgical care and drainage for the treatment of complex perianal fistulas in patients with Crohn*s disease (CD).

The effect of moderate alcohol consumption with a meal in different ambiances on postprandial mood, evaluated by subjective and objective responses.

Primary objective:To determine whether moderate alcohol consumption with a meal in different ambiances affects postprandial mood, evaluated by subjective (POMS, B-BAES, PPW questionnaires) and physiological (ACTH, cortisol, TRP:LNAA ratio, ghrelin…

Anti-inflammatory activity of strawberries: a human intervention trial

The aim of the proposed study is to evaluate the effect of daily consumption of 400 gram strawberries as smoothies during 2 weeks on markers of endothelial function, inflammation and oxidative stress.

Monosodium glutamate as a potential trigger for atrial fibrillation

To demonstrate the arrhythmogenic action of MSG in a single blinded placebo controlled test on these patients with reported MSG induced AF and to investigate the possibility of MSG as a potential trigger for AF.

A randomized, single-blind, placebo controlled, parallel-group study evaluating the anti-inflamatory activity of GSK315234 in synovial biopsy tissue obtained from subjects with rheumatoid arthritis (OSM105196)

Primary ObjectivesTo assess the change in inflammatory biomarkers in the synovial tissue of subjects with RA on a background of methotrexate after administration of a single, intravenous dose of GSK315234, as compared to placebo. To assess the…

A Randomised, Placebo Controlled, Ascending, Repeat Dose Study in Healthy Volunteers Investigating Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GSK356278

To investigate the safety and tolerability of repeat oral doses of GSK356278 in healthy volunteers.To investigate the pharmacokinetics of repeat oral doses of GSK356278 in healthy volunteers.To evaluate the PK/PD relationship between plasma…

Bioavailability of lutein from a lutein-enriched egg-yolk-beverage and its dried re-suspended versions.

The primary objective of this study is to investigate whether consumption of a dried lutein-enriched egg-yolk containing beverage significantly increases serum lutein concentration in healthy volunteers.A secondary objective is to investigate…

The Effect of Inhaled Salmeterol on Inflammation after Bronchial Instillation of Allergen or Allergen/Lipopolysaccharide in Asthma.

Salmeterol has an inhibitory effect on both allergen and allergen/LPS induced inflammation in asthmatics while on maintenance treatment with low dose corticosteroids.

Evaluation of the effect of the AlphaCoreTM on breathlessness and time to discharge in hospitalised subjects with COPD.

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Cost-effectiveness of cognitive behaviour therapy for recent onset schizophrenia patients with persistent and recurrent psychosis.

To determine the cost-effectiveness of CBT compared to care as usual in patients with a recent onzet of schizophrenia, who suffer from persistent and recurrent symptoms of psychosis.

The effects of consumption of vitamin E or lipoic acid on serum oxyphytosterol concentrations in subjects with impaired glucose tolerance or type II diabetes

The major objective of the present study is to examine the effect of consuming vitamin E (804 mg) or lipoic acid (600 mg) for 4 weeks on fasting oxyphytosterol concentrations in subjects with impaired glucose tolerance or type 2 diabetes.

UPFRONT - Prospective cohort study on early identification and treatment of adaptive deficits in mild to moderate traumatic brain injury - the impact of frontal network dysfunction for longterm outcome.

Objectives of the study: Project 1 - To assess early adaptive deficits in a multicentre cohort of mild to moderate TBI patients and their relation to outcome. Project 2 - Early intervention study of Cognitive Behavioural Therapy (CBT) to assess…

The effectiveness of Extracorporeal Shockwave therapy in the treatment of medial tibial stress syndrome*

Aim of this study is to determine the effectiveness of Extracorporeal Shockwave Therapy (ESWT) on degree of recovery after 3 months in patients with MTSS.

Attention Defficity Hyperactivity Disorder and fMRI neurofeedback: A randomized controlled trial on the effects of self-modulating anterior cingulate cortex activation levels.

The principal objective of this study will be to critically evaluate if the fMRI-neurofeedback training is successful in reducing ADHD symptoms and improving cognitive functioning. Thus, the first goal is to show that ADHD patients are able to…