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Effectiveness of eccentric calf muscle exercise therapy in patients with chronic midportion Achilles tendinopathy.

To evaluate the effectiveness of eccentric calf muscle exercise therapy compared to strength training of the upper extremities (control group) in patients with chronic midportion Achilles tendinopathy.

Cognitive Bias Modification: Exploring the effects of a computer-based cognitive bias training in oncology patients at risk for depression and anxiety symptoms -(OncoCogTrain)

The purpose of our study is to test the effect of a computer-based cognitive behavioral intervention (called Cognitive Bias Modification, CBM) on affective symptoms in oncology patients. Here we are collaborating with the Oncology department of the…

To examine the effect of dietary supplementation with fish oils and complex lipids on mitochondrial, physical, and cognitive function, in elderly humans.

The main objective of this study is to determine whether supplementation with FO combined with complex phospholipids can alter skeletal muscle mitochondrial function more effectively than FO alone. Additional exploratory objectives are;…

The effect of short-term Aronia melanocarpa extract supplementation on cognitive function in healthy young adults

With this research we look at the short-term effects of an aronia malanocarpa extract on cognitive functioning in healthy young adults compared to placebo.

Randomized, double-blind, placebo-controlled single ascending dose study to investigate the safety, tolerability, pharmacokinetics, pharmacodynamics and food-effects of YTX-7739, a novel oral inhibitor of Stearoyl-CoA-desaturases, in healthy volunteers

* Part A: To investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of increasing doses of YTX-7739 in healthy subjects. * Part B: To study the effect of food on pharmacokinetics of YTX-7739 in a selection of subjects who…

A multicenter, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of padsevonil as adjunctive treatment of focal-onset seizures in adult subjects with drug-resistant epilepsy

Objectives:Primary objective:To evaluate the efficacy of the 3 selected dose regimens of Padsevonil (PSL) administered concomitantly with up to 3 antiepileptic drugs (AEDs) compared with Placebo for treatment of observable focal-onset seizures in…

Randomized controlled trial to assess the effect of vitamin K supplementation on the rate of elastin degradation in COPD

To evaluate whether supplementation of vitamin K2 decelerates the rate of mature cross-linked elastin degradation inpatients with COPD.

A Phase IIb Randomized, Double-blind, Parallel Group, Placebo- and Active-controlled Study with Double-Blind Extension to Assess the Efficacy and Safety of Vamorolone in Ambulant Boys with Duchenne Muscular Dystrophy (DMD)

Primary objectives: 1. To compare the efficacy of vamorolone administered orally at daily doses of 6.0 mg/kg over a 24-week treatment period vs. placebo in ambulant boys ages 4 to <7 years with DMD; and2. To evaluate the safety and…

The effect of probiotics on gastrointestinal symptoms during endurance exercise and exercise performance in relation to the composition of the gut microbiota/metabolites.

Primary Objective: Can the chance at and/or intensity of gastrointestinal symptoms during exercise be influenced by probiotics supplementation in recreationally trained endurance athletes who experience these symptoms and can performance be enhanced…

Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging, Efficacy and Safety Study with Inhaled RVT-1601 for the Treatment of Persistent Cough in Patients with Idiopathic Pulmonary Fibrosis (IPF): SCENIC Trial

To assess the efficacy of inhaled RVT-1601 in comparison with placebo following 12 weeks of treatment

A phase IIa, placebo-controlled, double blind, randomised multicentre pilot study to investigate the efficacy, safety and tolerability of the monoclonal antibody ATH3G10 in patients with ST-elevation myocardial infarction

The main goal of this study is to evaluate efficacy of a single administration of ATH3G10 in patients presenting with an acute STEMI undergoing PCI.The primary objective is to investigate effects on left ventricular remodelling as measured by the…

Peri-Operative ISchemic Evaluation-3 Trial

Perioperative bleeding in the setting of noncardiac surgery is strongly associated with 30-day cardiovascular complications and mortality. Trial evidence suggests that intravenous TXA reduces perioperative bleeding and transfusion in orthopedic…

Randomized, Double-blind, Placebo-controlled, Two-Part, Adaptive Design Study of Safety, Tolerability, Preliminary Pharmacokinetics, and Pharmacodynamics of Single and Multiple Ascending Oral Doses of MYK-491 in Patients with Stable Heart Failure with Reduced Ejection Fraction

To establish preliminary safety and tolerability of single- and multiple-ascending oral doses of MYK 491 in ambulatory patients with stable heart failure with reduced ejection fraction (HFrEF)

A Phase 2b/3 study to evaluate the safety, tolerability, and effects of livoletide (AZP-531), an unacylated ghrelin analog, on food-related behaviors in patients with Prader-Willi syndrome

This Phase 2b/3 double-blind, placebo-controlled study will evaluate the safety, tolerability, and effects of livoletide on food-related behaviors in patients with Prader-Willi Syndrome (PWS).

A two-part, randomized, two-period, two-sequence crossover and placebo-controlled parallel group, phase 1B trial to evaluate the safety and pharmacokinetics of Modafinil administered in combination with Aniracetam in elderly subjects with subjective cognitive decline

The purpose of this study is to investigate how safe modafinil is and how well it is tolerated when it is administered in combination with aniracetam to generally healthy elderly volunteers with subjective cognitive decline. Modafinil and aniracetam…

Brain Stimulation for Mental Control

The study objective is to test the effect of a tDCS intervention in a sample of healthy military personnel. We investigate the effects of the intervention primarily on the intensity of fear reactions, and secondarily on cognitive performance and…

A multi-national, multi-centre, double-masked, placebo-controlled proof of concept trial to evaluate the safety and efficacy of oral soraprazan in Stargardt disease

Primary objective:To evaluate the efficacy of soraprazan in reducing the amount of lipofuscin inRPE cells of subjects with Stargardt disease by assessing the change inquantitative auto-fluorescence (qAF8) from baseline to after treatment…

A randomized, vehicle-controlled, double-blind, Phase I/IIa, multiple-dose, multiple-cohort, Proof of Concept study in Healthy Volunteers and Patients with Cutaneous T-cell Lymphoma to characterize the safety, efficacy, and pharmacodynamics of topical bimiralisib

HV cohort 1Primary Objectives* To characterize the local tolerability of topical bimiralisib after 21 days* To characterize the systemic PK of topical bimiralisib after 21 daysSecondary Objective* To characterize the safety of topical bimiralisib…

A randomized, placebo-controlled, double-blind, parallel arms study to evaluate the pharmacokinetic and pharmacodynamic relationship of multiple subcutaneous injections of apraglutide in healthy volunteers.

1. A better understanding of the apraglutide dose/concentration-effect relationship;2. A better understanding of duration of effect (apraglutide kinetics in relation to citrulline kinetics).

A randomized, double-blind, placebo-controlled, multicenter, phase 2a study to evaluate the safety, tolerability, and early proof of concept of TAK-018 for the prevention of postoperative Crohn*s disease recurrence.

Primary Objective:to assess the safety and tolerability of TAK-018 in postoperative subjects with CD afterlaparoscopic ileocecal resection with primary anastomosis.Secondary Objectives:to evaluate the impact of TAK-018 on intestinal inflammation…