16 results
To test whether tACS in a theta frequency enhances extinction of physiological stress responses to exposure to anxiety- or trauma-related stimuli or memories. Secondarily, to examine the influence of baseline neuroendocrinological response, baseline…
The aim of the study is to investigate whether standardized or personalized tACS induces EEG changes indicative of delirium reversal (primary outcome) or reduces the duration and/or severity of delirium (secondary outcome) compared to sham treatment…
A possible treatment approach is cognitive remediation training (CR), a training developed to target cognitive deficits with the ultimate aim to improve daily functioning. Participants engage in cognitive exercises, learn more about their own…
The aim of the study is to investigate whether inhibition of the left or right insula has differential effects with regard to clinical outcomes (i.e. smoking cessation/reduction), cognitive processes (i.e. cognitive control, craving and goal-…
In this trial, the researchers want to know how safe AZD8630 is and how well it works to control asthma symptoms when taken with the Saphira inhaler alongside their standard medication. Saphira is a new device that has been designed to deliver…
The primary aim of this study is to assess the efficacy of taVNS in mitigating the acute stress response induced by the Maastricht Acute Stress Task (MAST) among healthy subjects, measured by cortisol levels in saliva samples.Secondary objectives…
The primary objectives are to study the feasibility and acceptability of an 8-week daily oral supplementation with tributyrin (4 g/day) - the triglyceride form of butyric acid - on top of treatment as usual (TAU) in adults (18 up to 65 years) with…
Primary objective• Assess the ability of donepezil to reverse biperiden-induced effects on adaptive tracking performance at timepoint 4h Secondary objectives• Evaluate the PK of donepezil and biperiden• Investigation of pro-cholinergic effects of…
Primary objective: to study whether pyridoxamine supplementation in type 2 diabetes improves microvascular function in the eye, kidney and skin, and reduces markers of endothelial dysfunction and glycation.Secondary objective: to study whether…
To assses safety, gut engraftment and effects on sugar- and alcohol metabolism of d. piger in individuals with increased waist circumference.
Primary: To determine the efficacy and safety of bel-sar compared to sham control for thetreatment of primary indeterminate lesions and small choroidal melanoma (IL/CM).Secondary: To assess the systemic pharmacokinetics (PK) and immunogenicity of…
Primary: To determine the efficacy and safety of bel-sar compared to sham control for thetreatment of primary indeterminate lesions and small choroidal melanoma (IL/CM).Secondary: To assess the systemic pharmacokinetics (PK) and immunogenicity of…
Primary Objective: • To assess whether the food supplement Endocalyx lowers blood pressure in patients with treatment resistant hypertension.Secondary Objectives: • To study the effect of Endocalyx on office blood pressure and 24-hour blood pressure…
To assess whether 10 sessions of cTBS of the contralesional primary motor cortex combined with regular care upper limb training, started within three weeks after stroke onset, are effective and cost effective in promoting upper limb recovery after…
The primary goal is to demonstrate that in gastric esophageal cancer the addition of a microbiome intervention with fecal capsules from healthy donors can improve the effectiveness of perioperative chemotherapy as measured by the tumor regression…
This pilot study aims to assess the feasibility, safety and preliminary efficacy of a novel thermosensitive hyaluronic acid gel with an octenidine preservative system as an adjunct to standard non-surgical periodontal treatment. The use of a blinded…