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A methodological investigation to test acute changes in female sexual desire in healthy volunteers and pre- and postmenopausal women diagnosed with hypoactive sexual desire disorders using explicit measures in a controlled laboratory setting and behavioral measures at home, in no-drug as well as placebo-controlled within subjects cross-over drug (a single dose of testosterone gel 50mg [1% in 5g] conditions.

In order to better understand sexual desire (e.g., fluctuations in desire, level of desire to distinct sexual stimuli varying in intensity, subtypes of desire disorder) it is important to examine methods for rapid detection of desire changes.…

Randomized, double blind, placebo-controlled trial of ubiquinol in a statin-induced mitochondrial dysfunction model in healthy volunteers.

Primary Objectives-To evaluate if mitochondrial dysfunction can be induced in healthy, middle aged subjects, through the use of simvastatin, and whether it can be reversed by oral ubiquinol supplementation. -To validate the techniques NIRS, PpIX-…

A randomized, double-blind, placebo-controlled, cross-over study to assess the effects of fampridine on eye movements and nerve conduction and function in patients with multiple sclerosis (MS) and a unilateral or bilateral internuclear ophthalmoplegia (INO)

Primary objective: - to evaluate the effects of fampridine on eye movements in MS patients with a unilateral or bilateral INO. Secondary objectives:- to determine whether there is an association between MRI signal of the medial longitudinal…

Pilot study: Is concomitant administration of lidocaine during oxaliplatin infusion able to prevent pain as a result of oxaliplatin induced acute neuropathy?

Primary objectiveTo evaluate the efficacy of low dose intravenously lidocaine in comparison with placebo in terms of pain relief after the first oxaliplatin administration measured by a numeric rating scale (NRS 0-10).Secondary objectives1.…

Sensitization to lupine flour: is it clinically relevant?

We found a prevalence of 6% sensitization in patients with a possible food allergy. The aim of this study is to investigate if sensitization to lupine flour in atopic patients has clinical relevance. Additionally, we want to investigate if cross-…

A Double-masked, Placebo-controlled Study with Open-label Period to Evaluate the Efficacy and Safety of MEDI-551 in Adult Subjects with Neuromyelitis Optica and Neuromyelitis Optica Spectrum Disorders.

Primary Objective: To compare the efficacy of MEDI-551 versus placebo in reducing the risk of an NMO/NMOSD attack in subjects with NMO/NMOSD.Secondary Objectives:1. To compare the efficacy of MEDI-551 versus placebo on the reduction of EDSS…

Parallel-Group, Placebo-Controlled Randomized Study Investigating the Effect of Intravenous Iso-osmolar Iodinated Contrast Material Iodixanol (Visipaque* Injection 320 mgI/mL) on Renal Function in Adults with Chronic Kidney Disease (CKD) Stage III or Stage IV Who Have Undergone Endovascular Aneurysm Repair (EVAR)

Primary Objective:* To demonstrate the safety of intravenous (i.v.) iodinated iso-osmolar iodixanol (Visipaque* Injection 320 mgI/mL) usage in contrast-enhanced computed tomography (CECT) for CKD stage III/IV patients by evaluating the incidence of…

Immunisation, Treatment and Controlled Human Hookworm Infection

Primary objective:* To determine the protective efficacy of repeated short term exposure to hookworm infection Secondary objectives:1. To explore the immunological response after repeated hookworm infections2. To evaluate the safety of and number of…

Safety and protective efficacy of repeated controlled human Schistosoma mansoni Infection

Primary Objectives: - To determine the protective efficacy of repeated exposure to male Schistosoma mansoni (Sm) cercariae in healthy Schistosome-naïve volunteers based on CAA levels.- To determine the safety and tolerability of repeated exposure to…

Tina-quant Lp(a) RxDx Phase III Trial Sample Measurement

The objective of this study is to support the pharma partner*s Phase III trial using Tina-quant Lipoprotein (a) RxDx assay for subject selection and optional batch testing of follow-up samples. This study is carried out to evaluate the performance…

A visual-developmental perspective for children born very preterm

The main objective of this study is to investigate the effectiveness of early visual assessment and early rehabilitation of VPD in very preterm children (born <30 weeks GA), from 1 year CA.

A Phase 3, Randomized, Double-blind Trial of Pembrolizumab (MK-3475) Plus Enzalutamide Versus Placebo Plus Enzalutamide in Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC) (KEYNOTE-641)

This study has been transitioned to CTIS with ID 2022-500785-10-00 check the CTIS register for the current data. 1) To compare pembrolizumab plus enzalutamide versus placebo plus enzalutamide with respect to overall survival (OS)2) To compare…

A Phase 3, Randomized, Double-blind Study of Pembrolizumab (MK-3475) Plus Docetaxel Plus Prednisone versus Placebo Plus Docetaxel Plus Prednisone in Participants with Chemotherapy-naïve Metastatic Castration-Resistant Prostate Cancer (mCRPC) who have Progressed on a Next Generation Hormonal Agent (NHA) (KEYNOTE-921)

To compare pembrolizumab plus docetaxel plus prednisone to placebo plus docetaxel plus prednisone with respect to overall survival (OS)

The effect of intradialytic parenteral nutrition on nutritional status and quality of life in hemodialysis patients

The aim is to see whether intradialytic parenteral nutrition is an efective treatment against the loss of muscle mass

A randomized, double-blind, placebo-controlled, alternating panel single ascending dose, sequential multiple ascending dose, and food effect study of FM101 in healthy male and female volunteers

The purpose of this study is to investigate how safe the new compound FM101 is and how well it is tolerated when it is administered to healthy volunteers. FM101 has not been administered to humans before. It has been previously tested in the…

Combined effects of SGLT2 inhibition and GLP-1 receptor agonism on food intake, body weight and central satiety and reward circuits in obese T2DM patients

Primary objective:To investigate the separate and combined actions of the SGLT2 inhibitor dapagliflozin and GLP-1 receptor agonist exenatide on activity in central reward and satiety circuits in response to food related stimuli in obese patients…

The effect of dietary interventions on endothelial glycocalyx dimensions and barrier function in South Asian patients with diabetic nephropathy.

The primary aim of the study is to improve microvascular endothelial health after 3 months expressed by the Microvascular Healt Index, using a non-invasive imaging technique, upon two different dietary interventions compared to the placebo. The…

Efficacy of Diltiazem to improve coronary microvascular dysfunction: A randomized clinical trial

This study has been transitioned to CTIS with ID 2024-512030-15-00 check the CTIS register for the current data. Our primary objective is to assess the effect of diltiazem on coronary microvascular function as assessed by coronary reactivity testing…

Placebo-controlled double-blind randomized controlled trial investigating vitamin K supplementation on vascular calcification propensity in vitamin K deficient renal transplant recipients

To study the effect of vitamin K supplementation on calcification propensity and vitamin K status in RTRs with vitamin K deficiency.

Effects of vitamin K2 supplementation on [18]F-NaF PET/MRI in patients with carotid and coronary artery disease

To test our hypothesis that vitamin K2 supplementation will induce a clinically relevant reduction in the degree of micro-calcification from carotid artery disease patients, when comparing to a placebo, after 3 months.