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The Effect of Taurine on Morbidity and Mortality in the Elderly Hip Fracture Patient

Our primary objective is the effect of taurine on morbidity and consequent mortality.

Dissecting the mechanisms of fear formation: a pharmacological study with healthy volunteers

• To elucidate the role of noradrenaline in the mechanisms involved in human memory consolidation• Evaluate the levels of cortisol and 3-methoxy-4-hydroxyphenylglycol in the various points of a memory consolidation window• Define pharmacological…

The manipulation of dietary protein intake on the anabolic response in healthy young men

STUDY 1: To investigate the impact of prior ingestion of a single high protein meal on the normal obligatory increase of muscle protein synthesis rates after protein intake and physical activity in healthy young men. STUDY 2: To investigate the…

Effect of N3-polyunsaturated fatty acids on peripheral insulin sensitivity

to measure peripheral insulin sensitivity and intramyocellular concentrations of different FA metabolites (ceramide, gangliosides, diacylglycerol and triacylglycerol) known to interfere with the insulin signalling cascade during infusion of…

Meralgia paresthetica
a study of diagnosis, prognosis and treatment

A. What are possible causes of MP and what patients variable are asssociated with MP. What is the natural course and prognosis of MP. What is the influence of MP on the quality of life.B. What is the diagnostic value of SSEP en nerve conduction…

A randomized double blind placebo controlled ascending dose study to evaluate the effect of APL180 on endothelial function in patients with familial hypercholesterolemia

Assess whether APL180 can improve endothelial function in patients with Familial hypercholesterolemia

Respiratory infections in asthma: the role of host defense against infections, allergic inflammation and vitamin D

We hypothesize that local AMPs expression in the airways of patients with asthma is decreased as a result of allergic inflammation. Furthermore, we hypothesize that local AMP expression can partly be restored by vitamin D substitution therapy. We…

Does ATP cause Annexin A5 targeting in the human forearm?

To study the impact on intra-arterial ATP infusion on Annexin A5 targeting.

Diurnal and segmental variation in glucose sensing: effects on homeostasis, satiety and energy intake in healthy volunteers

The aim of this research is to determine the effect of glucose in the small intestine on the secretion of hormones, appetite related feelings and food intake, and whether these effects differ between time of day (morning vs evening) and segment of…

Pharmacological and genetic imaging of executive function deficits

With this study we want to identify the common aetiology and neurobiology of EFD, by employing pharmacological and genetic imaging in three neuropsychiatric disorders. We want to identify an underlying functional and structural model for EFD,…

Cerebrovascular effects of galantamine treatment in patients with Alzheimer's disease.

To provide an answer to the following questions: 1. In patients with AD, does treatment with a ChEI improve cerebral hemodynamics? 2. Is there less progression of cerebrovascular lesions on follow-up of AD patients receiving ChEI*s? 3. Does this…

The sensitivity of the pituitary thyrotrophs for ambient thyroid hormone levels.

The aim of this pilot study is;* To determine whether differences between individuals in the set-point of the HPT-axis can be determined by using this study-design,* To examine whether this study design is practicable and tolerated by the healthy…

Effect of dietary therapy with a probiotic mixture (Ecologic BARRIER) on the gut microbiome and fatigue symptoms in patients with quiescent inflammatory bowel disease - A clinical trial

To evaluate the effect of dietary therapy with a probiotic supplement on the composition of stool microbiome in fatigued IBD patients with quiescent diseaseTo define the effect of dietary therapy with a probiotic supplement on serum inflammatory…

Substance use and violence: development and validation of a test battery

Objective: To investigate whether persons under the influence of alcohol tend to be more aggressive (as measured by Point Subtraction Aggression Paradigm (PSAP) job and an attention task) than those receiving a placebo.In addition, the psychometric…

In vivo effects of amylase trypsin inhibitors from wheat in the human gut: proof of cause of non-coeliac wheat sensitivity in irritable bowel syndrome?

We aim to perform a proof-of-concept study to assess the effect of ATIs on the intestinal barrier and immune function in healthy volunteers. We hypothesise that the ATIs either directly affect the intestinal barrier function, or indirectly by…

The effect of intravenous lidocaine to prevent intracranial pressure increase in endotracheal intubation assessed by optic nerve sheath diameter

Primary Objective: To investigate the effect on the distention of the ONSD while using lidocaine 1,5 mg/kg IV during endotracheal intubation versus placebo. Secondary Objectives: The secondary objective of this study is to investigate the effect…

Efficacy and safety of minidosing lysergic acid diethylamide (LSD) for chronic cluster headache: a
randomized placebo-controlled study

This study has been transitioned to CTIS with ID 2024-520305-39-00 check the CTIS register for the current data. Primary objective: to evaluate the efficacy of LSD 25µg every 3 days for 3 weeks in cCH. Additional objectives:- To evaluate the safety…

Children Use Prebiotics via Digital/Day-care recruiting

This randomised double-blind placebo-controlled study will investigate the effects of a oligofructose vs a placebo on (change in) stool consistency in healthy children with hard stools. Other parameters to be investigated include (change in) stool…

The role of the adrenergic system in hypoglycaemia induced inflammatory response in people with type 1 diabetes and people without type 1 diabetes-RAID-II

To examine the effect of adrenergic inhibition on the hypoglycaemia induced inflammatory response (e.g. leukocyte phenotype, cytokines, inflammatory proteins) by performing a hyperinsulinaemic hypoglycaemic glucose clamp alongside infusion of α-ARA…

The effect of repeated sessions of whole-body neuromuscular electrical stimulation (NMES), with or without subsequent intake of a protein bolus, on muscle protein synthesis in healthy, young volunteers during 3 days of bed rest.

To investigate the effect of multiple sessions of whole body NMES, with or without consecutive protein intake, on muscle protein synthesis.