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Multicenter, double-blind, randomized, placebo-controlled, parallel-group study to assess the efficacy, safety and tolerability of tezosentan in patients with pre-operative pulmonary hypertension, due to left heart disease, undergoing cardiac surgery

Primary objective: to demonstrate that tezosentan, in patients undergoing cardiac surgery with cardiopulmonary bypass, reduces the incidence of clinically relevant right ventricular failure resulting in difficult separation from bypass or need for…

The adenosine receptor; a new pharmacological tool in the treatment of sepsis.

Does antagonism of the adenosine receptor by caffeine lead to an increased LPS-induced inflammatory reaction and an increase in (subclinical) tissuedamage?Does the C34T-polymorphism of the enzyme AMP-deaminase lead to a decreased inflammatory…

Effect of moderate alcohol consumption on postprandial insulin secretion, appetite regulation, glucose homeostasis and insulin resistance.

Objective: Primary objectives are to study the effects of moderate alcohol consumption on - Postprandial insulin secretion and pancreatic beta-cell function - Physiological and subjective parameters related to satiety and appetiteSecondary…

A Phase 1, Double-Blind, Placebo-Controlled, Dose-Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Doses of ISIS 325568 Administered to Healthy Volunteers

Primary:To evaluate the safety of a single subcutaneous injection of ISIS 325568 administered at four increasing dose levels (50, 100, 200, 400 mg/week) and to evaluate the safety and tolerability of multiple doses of ISIS 325568 (three intravenous…

A Double Blind, Randomized, Placebo Controlled, Multi-Center Trial of Anti-TNFα Chimeric Monoclonal Antibody (infliximab, Remicade®) in Combination with Methotrexate in Patients with Very Early Inflammatory Arthritis (DINORA Study)

The primary objective of the study is to demonstrate that patients with very early arthritis have a higher probability of achieving a state of clinical remission at end of infliximab therapy if treated with infliximab plus MTX when compared to MTX…

TIN FOIL FOR PREVENTION OF FANTOM LIMB PAIN AFTER A LOWER LEG AMPUTATION, CAUSED BY COMPLICATED VASCULAR DISEASE: a randomised cross-over study

application of tin foil on an amputated leg deminishes fantoom pain

A Phase III, Randomised, Parallel Group, Multi-Centre Study in Recurrent Glioblastoma Subjects to Compare the Efficacy of AZD2171 [RECENTIN] Monotherapy and the Combination of AZD2171 with Lomustine to the Efficacy of Lomustine Alone

The Primary Objective of the study is to dettermine the relative efficacy of AZD2171 [RECENTIN] (both monotherapy or in combination with oral lomustine) compared to oral lomustine alone by assessment of progression free survival (PFS) as assessed by…

Randomised, double-blind, placebo-controlled, single-dose, dose-escalation study of the safety, tolerability, and pharmacokinetics of Lu AA24493 in acute ischemic stroke

Objective of this first human study with Lu AA24493 is to evaluate the safety, tolerability, immunogenicity and pharmacokinetics of Lu AA 24493 in patients with acute ischemic stroke. In addition patient outcome on National Institutes of Health…

Dexamethasone for postoperative pain relief following tonsillectomy in children

To assess whether a single shot of dexamethasone reduces postoperative pain, and reduces the time children need to start with drinking and eating.

A study on the effects on plasma insulin and glucose after a single meal replacement (InsuVital) with or without added Leucine in patients with T2DM

Objectives:To assess the effect of a single meal replacement (InsuVital®) with or without added leucine on blood levels of insulin, C-peptide and glucose in patients with T2DM.

The impact of macronutrient composition of an energy bar on postprandial blood glucose kinetics

The aim of the study is to compare glycemic responses after consumption of a standard (carbohydrate dense) energy bar and an energy bar with modified macronutrient composition.

A Phase 2/3, Double-Blind, Randomized, Placebo-Controlled, Multi-center, International Study to Evaluate the Efficacy and Safety of Oxabact(TM) to Reduce Urinary Oxalate in Subjects with Primary Hyperoxaluria.

Primary Objective:To evaluate the efficacy of Oxabact TM to reduce urinary oxalate levels from Baseline to Week 24 in subjects with Primary Hyperoxaluria (PH).Secondary Objectives:To evaluate:* Percentage of subjects who have 20% or greater…

A Phase IV Clinical Trial to Evaluate the Safety and Tolerability of ZOSTAVAX in Subjects >=60 Years of Age

The objective of the study is to evaluate the general safety of ZOSTAVAX* in subjects >=60 years of age.

A randomized, double blind, placebo-controlled, double dummy, three-way crossover study to investigate the effects of an intravenous ethanol clamp and a morphine infusion on resting state functional magnetic resonance imaging in healthy male volunteers

Primary Objectives:• To investigate the effects of a stable level of alcohol (0.6 g/L) on fMRI activation patterns in healthy male volunteers,• To investigate the effect of a stable level of morphine (80 nmol/L) on fMRI activation patterns in…

Acute effects of coffee and major coffee components on glucagon-like peptide 1 response and glucose tolerance in humans

To test whether chlorogenic acid and trigonelline ingestion acutely reduce postprandial glucose concentrations in humans. In addition, we will examine whether effects on glucagon-like peptide 1 secretion and dipeptidyl peptidase IV inhibition are…

A Double-Blind clinical trial of Benfotiamine Treatment in Diabetic Nephropathy

-To investigate whether a short-term treatment (3 months) with benfotiamine in diabetic nephropathy patients leads to a reduction in urinary excretion of β2-microglobulin and albumin.-To investigate whether short-term treatment (3 months) with…

A Double-Blind, Randomized Study to Evaluate the Efficacy and Safety of Lapaquistat Acetate 50 mg versus Placebo in Subjects with Hypercholesterolemia, With an Optional Open-Label Extension

The main objective of this study is to further determine the efficacy of lapaquistat acetate 50mg compared to placebo during a period of 12 weeks. This period is followed by an optional 48 week open label extension to be able to study the long term…

A Phase II, international, multi-centre, prospective, randomised, parallel-group, double-blind, dose-ranging, placebo-controlled, 12-week, princeps study to assess the efficacy and safety of a one injection cycle with either botulinum toxin type-A (Dysport® 125, 250 or 500 units) or placebo followed by an optional 6-month extension phase in the symptomatic treatment of micturition urgency and frequency in continent female subjects suffering from idiopathic overactive bladder.

Primary Objective: To assess the effect of treatment with three doses of botulinum toxin type-A (Dysport®) versus placebo on the number of episodes of urgency and frequency of micturition experienced in continent female subjects with idiopathic…

A 12-Week, Double-Blind, Randomized, Placebo-Controlled Study in Type 2 Diabetes Mellitus Subjects to Evaluate the Efficacy, Safety and Tolerability of MTP Inhibitor JNJ-16269110

The primary objective of this study is to evaluate the effect of 12-week treatment with JNJ-16269110 on the glycated hemoglobin (HbA1c) concentration in subjects with T2DM.Additional objectives are to evaluate the effect of JNJ-16269110 on:1.…

A Phase 3, Multicenter, Randomized, Double-blind Study Comparing the Safety and Efficacy of ABT-874 to Methotrexate in Subjects with Moderate to Severe Chronic Plaque Psoriasis.

To compare the short-term and long-term clinical efficacy, safety and tolerability of ABT-874 compared to MTX in the treatment of moderate to severe chronic plaque psoriasis over a 24 and 52-week period.