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Effects of fenofibrate and fish oil on gene expression and metabolic changes in obese subjects

The objective of this study is to compare in obese subjects the effects of fenofibrate (200 mg/day) with those of fish oil (7.2 g/day) on expression of PPARα related genes and metabolic parameters.

The role of adrenal stress hormones in emotional memory: formation, consolidation, and reconsolidation

-Identify the neural correlates of enhanced formation of emotional memory, and parse the role of adrenal stress hormones in this process.-Identify the neural correlates of enhanced consolidation of emotional memory and parse the role of adrenal…

Pharmacological and genetic imaging of executive function deficits

With this study we want to identify the common aetiology and neurobiology of EFD, by employing pharmacological and genetic imaging in three neuropsychiatric disorders. We want to identify an underlying functional and structural model for EFD,…

A Randomized, Double-blind, Multicenter, Phase 2 Study of a Human Monoclonal Antibody to Human aV Integrins (CNTO 95) in Combination With Docetaxel and Prednisone for the First-Line Treatment of Subjects With Metastatic Hormone Refractory prostate Cancer

Evaluate the efficacy and safety of treatment with CNTO 95 in combination with docetaxel and prednisone compared with docetaxel and prednisone without CNTO 95 in subjects with metastatic HRPC.

A methodological investigation to test acute changes in female sexual desire in healthy volunteers and pre- and postmenopausal women diagnosed with hypoactive sexual desire disorders using explicit measures in a controlled laboratory setting and behavioral measures at home, in no-drug as well as placebo-controlled within subjects cross-over drug (a single dose of testosterone gel 50mg [1% in 5g] conditions.

In order to better understand sexual desire (e.g., fluctuations in desire, level of desire to distinct sexual stimuli varying in intensity, subtypes of desire disorder) it is important to examine methods for rapid detection of desire changes.…

'The effects of Omega-3 Fatty Acids Dietary Supplements (Fish Oil) on Impulsivity in Patients with a Personality Disorder'

The primary research question of this study is:*What is the effect of omega-3 fatty acids dietary supplementation compared to placebo in the treatment of impulsivity in patients with a personality disorder?*The secondary research question of this…

A Double-Blind, Placebo-Controlled, Randomized, Multiple Ascending Oral Dose Study to Investigate The Safety, Tolerability, Pharmacokinetics And Pharmacodynamics of JNJ-26070109 In Healthy Subjects

JNJ-2607019 is an investigational drug being developed for gastroesophageal reflux disease (GERD) to reduce the complaints of abdominal pain and heartburn in people with this disease. JNJ-26070109 inhibits the gastrin receptor in the stomach. The…

A Blinded, Placebo-Controlled, Randomized, Single Ascending Dose Study in Healthy Male Subjects to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of JNJ-37822681

The objectives for the study are:to investigate the safety and tolerability of JNJ-37822681 following single dose administrations in healthy male subjects.to investigate the plasma pharmacokinetic profile of JNJ-37822681 and metabolites after single…

A randomised, double blind placebo controlled trial to (A) assess the optimal vitamin K dosage for supplementation, and (B) to access wether complications of anticoagulation treatment will diminish by suppletion of vitamin K.

VIKS-2A:To determine the optimal dosage of vitamin K for supplementation to obtain a stable anticoagulation effect.VIKS-2B:To determine whether supplementation with the found optimal dosage of vitamin K from study VIKS-2A will decrease the number of…

Efficacy of a mamma fieldblock in oncological breast surgery in reducing postoperative nausea and pain.

Reducing postoperative pain and nausea improves patient satisfaction.

A Multicenter, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study of the Safety and Efficacy of a Single Treatment with Two Dose Levels of BOTOX?? (Botulinum Toxin Type A) Purified Neurotoxin Complex Followed by a Treatment with BOTOX?? in Patients with Urinary Incontinence Due to Neurogenic Detrusor Overactivity

Objective: The principal objective is to evaluate the safety and efficacy of two doses of BOTOX (200 Units or 300 Units) compared with placebo injected into the bladder wall in patients who have urinary incontinence due to neurogenic detrusor…

Doxycycline for Stabilization of Abdominal Aortic Aneurysms

To test whether 100 mg doxycycline inhibits aneurysm growth

Pre-incisional bupivacaine infiltration of trocarincisions, reduction of postoperative pain in laparoscopic cholecystectomy?

The purpose of this study is to monitor whether preicncisional bupivacaine (bupivacaïne 0,5% with epinefrine 1:200.000), infiltration in trocarcincisions reduces postoperative wound pain in patients undergoing laparoscopic cholecystectomy.

Clinical effects of low dose pipamperone (Dipiperone) versus placebo on cognitive functions of elderly patients suffering from cognitive dysfunction, admitted at a general hospital.

To asses the clinical effect of low dose pipamperone on cognitive functions of elderly patients suffering from cognitive dysfunction.

A Multicenter, Double-blind, Randomized, Parallel, Placebo-controlled Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of 2 Oral Doses, 25 mg Twice Daily and 100 mg Twice Daily, of PG 760564 in Adult Patients with Rheumatoid Arthritis Receiving Methotrexate

The objectives of this study are as follows:Primary Efficacy Objective:• To assess the effect of PG-760564 on the proportion of patients meeting the American College of Rheumatology 20 response criteria (ACR 20) at 12 weeks;11Secondary Efficacy…

Pre-incisional bupivacaine infiltration trocarincions, reduction of postoperative pain?

The purpose of this study is to monitor whether preicncisional bupivacaine (bupivacaïne 0,5% with epinefrine 1:200.000), infiltration in trocarcincisions reduces postoperative wound pain.

The effect of glycopyrroniumbromide on hypersalivation in patients with Parkinson's disease: a randomised, cross-over, doubleblind, placebocontrolled trial.

The aim of this study is to prove the efficacy of 3 times daily 1 mg glycopyrronium bromide admixture versus placebo admixture in patients with PD with hypersalivation. Furthermore, the safety of glycopyrronium bromide used in the mentioned dosage…

Misoprostol in the management of retained placenta, a safe alternative for manual removal? A randomised controlled trial.

The use of 800 mcg of misoprostol prevents manual removal of the retained placenta in 80% of cases.

The Effects of SCH 351125 on Mononuclear Cell Trafficking to Joints, Synovial Inflammation and Expression of Chemokines in Subjects With Rheumatoid Arthritis (Protocol No. P03653).

SCH 351125 50 mg BID 2/days is an effective treatment for RA.

A randomized, double blind, placebo-controlled trial to evaluate the clinical efficacy and the structure modifying properties of etanercept 50/25 mg sc weekly in patients with erosive OA of the interphalangeal finger joints.

Etanercept is able to improve clinical and functional abnormalities and to halt or reverse radiographic changes in inflammatory erosive hand osteoarthritis by virtue of blocking a major pro-inflammatory cytokine, tumor necrosis factor (TNF).